| Intravenous isosorbide dinitrate infusion in the management of unstable angina pectoris refractory to conventional medical therapy. | |
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MedLine Citation:
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PMID: 3669269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the past 2 years, 102 patients were treated for unstable angina pectoris (AP) in our department. Fifteen of them had recurrent chest pain at rest despite treatment with various anti-anginal agents, or prolonged chest pain unresponsive to sublingual nitroglycerin; they received intravenous isosorbide dinitrate (ISDN) infusion. A rapid bolus injection of 2 to 6 mg followed by an infusion of 2 to 5 mg/hr was given to 10 patients with acute chest pain, and 5 patients, who were free of chest pain at the time, but had repeated episodes of angina in the past 24 hours, were given ISDN infusion without a bolus injection. Chest pain disappeared completely in 13 patients, but recurred in 2 of them when the dose was tapered. Two other patients experienced recurrent chest pain during ISDN infusion, and additional boluses were given. The hospital course was uneventful in 11 patients. Four patients who had recurrent anginal attacks underwent emergency coronary cineangiography under intraaortic ballon counterpulsation and aorto-coronary bypass surgery. There were no hospital deaths, no one had subsequent acute myocardial infarctions, and only 2 patients had mild to moderate headache as a side effect. Although the patient population is small, intravenous ISDN infusion is useful in the management of severe unstable AP. |
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Authors:
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Y Hirota; T Saito; Y Kita; M Kino; Y Kitaura; S Kubo; K Kawamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 51 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-11-27 Completed Date: 1987-11-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 617-23 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aged, 80 and over Angina Pectoris / drug therapy* Angina, Unstable / diagnosis, drug therapy* Dose-Response Relationship, Drug Drug Evaluation Electrocardiography Female Humans Infusions, Intravenous Isosorbide Dinitrate / administration & dosage* Male Middle Aged Recurrence Time Factors |
| Chemical | |
Reg. No./Substance:
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87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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