| Intravenous iron replacement for persistent iron deficiency anemia after Roux-en-Y gastric bypass. | |
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MedLine Citation:
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PMID: 22867554 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Iron deficiency is a major postoperative complication of Roux-en-Y gastric bypass surgery. Oral replacement can fail to correct the deficiency. Thus, recourse to parenteral iron administration might be necessary. Our objective was to evaluate the effectiveness and safety of a standardized 2 g intravenous iron dextran infusion in the treatment of iron deficiency after Roux-en-Y gastric bypass surgery. The setting was a university-affiliated community hospital in the United States. METHODS: We reviewed the medical records of 23 patients at our institution who had received 2 g of iron dextran intravenously for recalcitrant iron deficiency after Roux-en-Y gastric bypass surgery. We obtained the demographic data and the complete blood count and serum iron studies obtained before treatment and at outpatient visits after infusion. RESULTS: Before treatment, all 23 patients were iron deficient (average ferritin 6 ng/mL) and anemic (average hemoglobin 9.4 g/dL). By 3 months, the average ferritin and hemoglobin had increased to 269 ng/mL and 12.3 g/dL, respectively. The hemoglobin levels remained stable throughout the follow-up period. The iron stores were adequately replaced in most patients. Four patients required a repeat infusion by 1 year, because the ferritin levels had decreased to <15 ng/mL. The probability of remaining in an iron replete state was 84.6% (95% confidence interval 78-91.2%). One patient required warm compresses for superficial phlebitis. No other significant adverse events were reported. CONCLUSION: Intravenous administration of 2 g of iron dextran corrects the anemia and repletes the iron stores for ≥1 year in most patients. This therapy is safe, tolerable, efficient, and effective. |
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Authors:
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Zachariah Defilipp; John Lister; Daniel Gagné; Richard K Shadduck; Lori Prendergast; Margaret Kennedy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-2 |
Journal Detail:
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Title: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Volume: - ISSN: 1878-7533 ISO Abbreviation: Surg Obes Relat Dis Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-8-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233161 Medline TA: Surg Obes Relat Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, West Penn Allegheny Health System, Pittsburgh, Pennsylvania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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