Document Detail

Intravenous infusions of heparin and penicillins.
MedLine Citation:
PMID:  4750455     Owner:  NLM     Status:  MEDLINE    
The chemical stability and anticoagulant activity of heparin (20 U/ml) were studied in five intravenous fluids at room temperature. Heparin remained stable and active for 24 hours in normal saline, but there was a rapid inactivation of 40 to 55% in solutions containing dextrose or lactate, as measured by chemical and biological methods.High concentrations of benzylpenicillin, ampicillin, or methicillin had no effect on heparin activity in normal saline or dextrose 5%: nor was the stability of the penicillins in these fluids affected to any marked extent by the presence of heparin. Ampicillin was, however, found to be unstable in dextrose 5%, and it would be preferable for it not to be added to dextrose infusions. It is concluded that heparin may be given intravenously in normal saline with benzylpenicillin, ampicillin, or methicillin but several other antibiotics were found to be unsuitable for concurrent infusion with heparin.
J Jacobs; D Kletter; E Superstine; K R Hill; B Lynn; R A Webb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  26     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1973 Oct 
Date Detail:
Created Date:  1974-01-11     Completed Date:  1974-01-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  AIM; IM    
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MeSH Terms
Ampicillin / administration & dosage
Cephaloridine / administration & dosage
Drug Combinations
Drug Stability
Erythromycin / administration & dosage
Gentamicins / administration & dosage
Glucose / administration & dosage
Heparin / administration & dosage*
Infusions, Parenteral
Kanamycin / administration & dosage
Lactates / administration & dosage
Methicillin / administration & dosage
Oxytetracycline / administration & dosage
Penicillin G / administration & dosage
Penicillins / administration & dosage*
Sodium Chloride / administration & dosage
Time Factors
Reg. No./Substance:
0/Anticoagulants; 0/Drug Combinations; 0/Gentamicins; 0/Lactates; 0/Penicillins; 114-07-8/Erythromycin; 50-59-9/Cephaloridine; 50-99-7/Glucose; 59-01-8/Kanamycin; 61-32-5/Methicillin; 61-33-6/Penicillin G; 69-53-4/Ampicillin; 7647-14-5/Sodium Chloride; 79-57-2/Oxytetracycline; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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