| Intravenous infusions of heparin and penicillins. | |
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MedLine Citation:
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PMID: 4750455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The chemical stability and anticoagulant activity of heparin (20 U/ml) were studied in five intravenous fluids at room temperature. Heparin remained stable and active for 24 hours in normal saline, but there was a rapid inactivation of 40 to 55% in solutions containing dextrose or lactate, as measured by chemical and biological methods.High concentrations of benzylpenicillin, ampicillin, or methicillin had no effect on heparin activity in normal saline or dextrose 5%: nor was the stability of the penicillins in these fluids affected to any marked extent by the presence of heparin. Ampicillin was, however, found to be unstable in dextrose 5%, and it would be preferable for it not to be added to dextrose infusions. It is concluded that heparin may be given intravenously in normal saline with benzylpenicillin, ampicillin, or methicillin but several other antibiotics were found to be unsuitable for concurrent infusion with heparin. |
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Authors:
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J Jacobs; D Kletter; E Superstine; K R Hill; B Lynn; R A Webb |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 26 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1973 Oct |
Date Detail:
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Created Date: 1974-01-11 Completed Date: 1974-01-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 742-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ampicillin
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administration & dosage Anticoagulants Cephaloridine / administration & dosage Drug Combinations Drug Stability Erythromycin / administration & dosage Gentamicins / administration & dosage Glucose / administration & dosage Heparin / administration & dosage* Humans Infusions, Parenteral Kanamycin / administration & dosage Lactates / administration & dosage Methicillin / administration & dosage Oxytetracycline / administration & dosage Penicillin G / administration & dosage Penicillins / administration & dosage* Sodium Chloride / administration & dosage Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Drug Combinations; 0/Gentamicins; 0/Lactates; 0/Penicillins; 114-07-8/Erythromycin; 50-59-9/Cephaloridine; 50-99-7/Glucose; 59-01-8/Kanamycin; 61-32-5/Methicillin; 61-33-6/Penicillin G; 69-53-4/Ampicillin; 7647-14-5/Sodium Chloride; 79-57-2/Oxytetracycline; 9005-49-6/Heparin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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