| Intravenous infusion of n-3 polyunsaturated fatty acids and inducibility of ventricular tachycardia in patients with implantable cardioverter defibrillator. | |
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MedLine Citation:
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PMID: 20356911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Marine n-3 polyunsaturated fatty acids (PUFA) may have antiarrhythmic effects. The aim of this study was to investigate the effect of intravenously administered n-3 PUFA on the inducibility of ventricular tachycardia (VT) in patients with an implantable cardioverter defibrillator (ICD). METHODS AND RESULTS: In a randomized, placebo-controlled cross-over study, patients with an ICD underwent two electrophysiological studies using the stimulation possibilities in the ICD preceded by intravenous infusion of either a lipid emulsion delivering 3.9 g n-3 PUFA or placebo (0.9% saline). The level of stimulation required to induce sustained monomorphic VT was ranked in order from least to most aggressive, and non-inducibility was ranked highest. The content of n-3 PUFA in plasma free fatty acids (FFA), plasma phospholipids, and platelet phospholipids was measured by gas chromatography. Eight patients were included, and six of these completed the study. The content of n-3 PUFA as FFA and in platelet phospholipids increased more after n-3 PUFA infusion than after placebo (P<0.001). Of the five patients who were inducible after placebo, two were no longer inducible after n-3 PUFA infusion and another two required stronger stimulation to induce VT. The difference in the stimulation required after placebo and after n-3 PUFA was borderline significant (P=0.063, Wilcoxon signed-rank test). CONCLUSION: Intravenous n-3 PUFA tended to decrease VT inducibility, but a larger study is warranted. |
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Authors:
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Trine Madsen; Jeppe Hagstrup Christensen; Anna Margrethe Thøgersen; Erik Berg Schmidt; Egon Toft |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-03-31 |
Journal Detail:
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Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 12 ISSN: 1532-2092 ISO Abbreviation: Europace Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
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Languages: eng Pagination: 941-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, and Department of Health Sciences and Technology, Aalborg University, Hobrovej, Aalborg 9000, Denmark. trine.madsen@rn.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiotonic Agents
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administration & dosage* Cross-Over Studies Defibrillators, Implantable* Fatty Acids, Omega-3 / administration & dosage* Female Humans Infusions, Intravenous Male Placebo Effect Tachycardia, Ventricular / diagnosis*, drug therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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