Document Detail


Intravenous infusion of magnesium sulphate after acute myocardial infarction: effects on arrhythmias and mortality.
MedLine Citation:
PMID:  2427458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two hundred patients with acute myocardial infarction were entered into a randomised double-blind trial where they received either intravenous magnesium sulphate or saline for 24 hours after admission to hospital. The incidence of ventricular arrhythmias necessitating treatment was reduced by more than half in the group receiving magnesium sulphate. There were two deaths in the group receiving magnesium sulphate and seven receiving saline placebo. Total cardiac events were significantly reduced in the magnesium treated group. These reductions cannot be attributed to differences in risk factors or therapy between the two groups, either before or during the period of study. These results suggest that magnesium administration reduces the incidence of serious tachyarrhythmias and death after acute myocardial infarction and that this simple regime warrants further study.
Authors:
L F Smith; A M Heagerty; R F Bing; D B Barnett
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of cardiology     Volume:  12     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-08     Completed Date:  1986-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / drug therapy*
Cardiac Complexes, Premature / drug therapy
Clinical Trials as Topic
Coronary Care Units
Double-Blind Method
Electrocardiography
Female
Heart Ventricles / drug effects
Humans
Infusions, Parenteral
Magnesium Sulfate / therapeutic use*
Male
Middle Aged
Myocardial Infarction / drug therapy*
Prognosis
Random Allocation
Tachycardia / drug therapy
Chemical
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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