Document Detail


Intravenous immunoglobulins and haematopoietic growth factors in the prevention and treatment of neonatal sepsis: ground reality or glorified myths?
MedLine Citation:
PMID:  17313617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal sepsis is a significant cause of morbidity and mortality in the neonatal intensive care unit. The epidemiology of neonatal infections is complex; however, they are in large part secondary to developmentally immature host defence mechanisms. These immunodeficiencies, which are exaggerated in premature and sick neonates, include quantitative and qualitative deficits in phagocytes, complement components, cytokines and immunoglobulins. Therapies that modulate or augment host defences may attenuate the virulence of neonatal infections. In this paper, we have reviewed immunotherapies that modulate the immune system of the neonate, including intravenous immunoglobulins and myeloid haematopoietic growth factors. Future studies should focus on investigating other abnormalities of neonatal host defence and/or combined immunotherapy approaches in an attempt to circumvent the immaturity of host defence and potentially reduce both the incidence and severity of neonatal sepsis.
Authors:
C K Shaw; A Thapalial; P Shaw; K Malla
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical practice     Volume:  61     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  482-7     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Manipal College of Medical Sciences (MCOMS), Pokhara, Nepal. shaw_1974@rediffmail.com
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MeSH Terms
Descriptor/Qualifier:
Developing Countries
Feasibility Studies
Hematopoietic Cell Growth Factors / therapeutic use*
Humans
Immunoglobulins, Intravenous / therapeutic use*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology,  physiopathology,  prevention & control
Sepsis / epidemiology,  physiopathology,  prevention & control*
Chemical
Reg. No./Substance:
0/Hematopoietic Cell Growth Factors; 0/Immunoglobulins, Intravenous

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