Document Detail


Intravenous immunoglobulin treatment of pregnant patients with recurrent pregnancy losses associated with antiphospholipid antibodies.
MedLine Citation:
PMID:  8382439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of high dose iv-immunoglobulin on antiphospholipid antibody levels and on pregnancy outcome was studied in one patient with secondary (SLE) and two patients with primary antiphospholipid syndrome during their four pregnancies. These three women had had two pulmonary embolies related to pregnancy and estrogen containing pills, 13 miscarriages and only one liveborn after pre-eclamptic pregnancy. During the four pregnancies the patients also received 75 mg of aspirin per day. Progressive depression of IgG-anticardiolipin antibody titer was observed after repetitive high dose iv-immunoglobulin (1 g/kg body-weight) infusions. The effects on lupus anticoagulant were variable. Three pregnancies ended in a delivery of healthy child after 36-38 weeks of gestation and one preterm child (34 weeks), with slight respiratory distress syndrome, was born. Our results support the idea that the addition of iv-immunoglobulin to aspirin prophylaxis is worth considering when the patient has a severe antiphospholipid syndrome and/or is refractory to usual treatments.
Authors:
R Kaaja; H Julkunen; P Ammälä; T Palosuo; P Kurki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  72     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-25     Completed Date:  1993-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology,  immunology,  therapy*
Adult
Antibodies, Antiphospholipid / blood
Antiphospholipid Syndrome / complications,  immunology,  therapy*
Aspirin / therapeutic use*
Drug Therapy, Combination
Female
Humans
Immunoglobulins, Intravenous / therapeutic use*
Lupus Erythematosus, Systemic / complications,  drug therapy*,  immunology
Pregnancy
Pregnancy Complications / immunology,  therapy*
Pregnancy Outcome
Recurrence
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Immunoglobulins, Intravenous; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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