Document Detail


Intravenous immunoglobulin therapy for scleromyxedema: a case report and review of literature.
MedLine Citation:
PMID:  20232589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Scleromyxedema is a chronic, idiopathic disorder characterized by cutaneous dermal mucin deposition in association with increased dermal collagen and absence of thyroid disease. The clinical features involve sclerosis of skin with numerous, 2-3 mm, firm, waxy, papules in a symmetrical distribution pattern. The skin lesions may progress to widespread and indurated plaques resulting in patient disability via decreased mobility, sclerodactyly and microstomia. Abnormalities in the muscular, neurologic, rheumatologic, pulmonary, renal and cardiovascular systems may accompany the cutaneous lesions. Multiple attempts at therapeutic interventions have failed due to inconsistent, unsatisfactory results and/or severe adverse effects. Herein, the authors describe a case of scleromyxedema successfully treated with high-dose intravenous immunoglobulin (hdIVIG).
Authors:
Novie Sroa; Shannon Campbell; Mark Bechtel
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  9     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-5     Citation Subset:  IM    
Affiliation:
Division of Dermatology, Ohio State University Medical Center, Columbus, OH 43221, USA. novie.sroa@osumc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Humans
Immunoglobulins, Intravenous / therapeutic use*
Male
Scleromyxedema / drug therapy*
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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