|Intravenous immunoglobulin therapy: how does IgG modulate the immune system?|
|PMID: 23411799 Owner: NLM Status: MEDLINE|
|Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the serum of thousands of donors and were initially used as an IgG replacement therapy in immunocompromised patients. Since the discovery, more than 30 years ago, that IVIG therapy can ameliorate immune thrombocytopenia, the use of IVIG preparations has been extended to a wide range of autoimmune and inflammatory diseases. Despite the broad efficacy of IVIG therapy, its modes of action remain unclear. In this Review, we cover the recent insights into the molecular and cellular pathways that are involved in IVIG-mediated immunosuppression, with a particular focus on IVIG as a therapy for IgG-dependent autoimmune diseases.|
|Inessa Schwab; Falk Nimmerjahn|
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|Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2013-02-15|
|Title: Nature reviews. Immunology Volume: 13 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2013 Mar|
|Created Date: 2013-02-25 Completed Date: 2013-04-18 Revised Date: 2014-06-03|
Medline Journal Info:
|Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England|
|Languages: eng Pagination: 176-89 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Autoantibodies / immunology
Autoimmune Diseases / immunology, therapy
Cell Adhesion Molecules / immunology
Clinical Trials as Topic
Disease Models, Animal
Histocompatibility Antigens Class I / immunology
Immunoglobulin Fc Fragments / immunology
Immunoglobulin G / immunology, pharmacology, therapeutic use*
Immunoglobulin Variable Region / immunology
Immunoglobulins, Intravenous / pharmacology, therapeutic use*
Immunomodulation / drug effects*, immunology
Inflammation / immunology, therapy
Lectins, C-Type / immunology
Lymphocyte Subsets / immunology
N-Acetylneuraminic Acid / immunology
Protein Processing, Post-Translational
Receptors, Cell Surface / immunology
Receptors, Fc / immunology
Receptors, IgG / chemistry, classification, immunology
|0/Autoantibodies; 0/Cell Adhesion Molecules; 0/DC-specific ICAM-3 grabbing nonintegrin; 0/Fc receptor, neonatal; 0/Histocompatibility Antigens Class I; 0/Immunoglobulin Fc Fragments; 0/Immunoglobulin G; 0/Immunoglobulin Variable Region; 0/Immunoglobulins, Intravenous; 0/Lectins, C-Type; 0/Receptors, Cell Surface; 0/Receptors, Fc; 0/Receptors, IgG; GZP2782OP0/N-Acetylneuraminic Acid|
Nat Rev Immunol. 2014 May;14(5):349
Nat Rev Immunol. 2014 May;14(5):349 [PMID: 24762829 ]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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