Document Detail

Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
MedLine Citation:
PMID:  23411799     Owner:  NLM     Status:  MEDLINE    
Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the serum of thousands of donors and were initially used as an IgG replacement therapy in immunocompromised patients. Since the discovery, more than 30 years ago, that IVIG therapy can ameliorate immune thrombocytopenia, the use of IVIG preparations has been extended to a wide range of autoimmune and inflammatory diseases. Despite the broad efficacy of IVIG therapy, its modes of action remain unclear. In this Review, we cover the recent insights into the molecular and cellular pathways that are involved in IVIG-mediated immunosuppression, with a particular focus on IVIG as a therapy for IgG-dependent autoimmune diseases.
Inessa Schwab; Falk Nimmerjahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-15
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-04-18     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  176-89     Citation Subset:  IM    
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MeSH Terms
Autoantibodies / immunology
Autoimmune Diseases / immunology,  therapy
Cell Adhesion Molecules / immunology
Clinical Trials as Topic
Disease Models, Animal
Histocompatibility Antigens Class I / immunology
Immunocompromised Host
Immunoglobulin Fc Fragments / immunology
Immunoglobulin G / immunology,  pharmacology,  therapeutic use*
Immunoglobulin Variable Region / immunology
Immunoglobulins, Intravenous / pharmacology,  therapeutic use*
Immunomodulation / drug effects*,  immunology
Inflammation / immunology,  therapy
Lectins, C-Type / immunology
Lymphocyte Subsets / immunology
Models, Molecular
N-Acetylneuraminic Acid / immunology
Protein Conformation
Protein Processing, Post-Translational
Receptors, Cell Surface / immunology
Receptors, Fc / immunology
Receptors, IgG / chemistry,  classification,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/Cell Adhesion Molecules; 0/DC-specific ICAM-3 grabbing nonintegrin; 0/Fc receptor, neonatal; 0/Histocompatibility Antigens Class I; 0/Immunoglobulin Fc Fragments; 0/Immunoglobulin G; 0/Immunoglobulin Variable Region; 0/Immunoglobulins, Intravenous; 0/Lectins, C-Type; 0/Receptors, Cell Surface; 0/Receptors, Fc; 0/Receptors, IgG; GZP2782OP0/N-Acetylneuraminic Acid
Comment In:
Nat Rev Immunol. 2014 May;14(5):349   [PMID:  24762828 ]
Nat Rev Immunol. 2014 May;14(5):349   [PMID:  24762829 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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