Document Detail

Intravenous immunoglobulin for prevention of sepsis in preterm and low birth weight infants.
MedLine Citation:
PMID:  3099267     Owner:  NLM     Status:  MEDLINE    
The effect of an intravenous polyvalent immunoglobulin preparation given prophylactically to prevent neonatal sepsis was tested in preterm and low birth weight infants. Infants matched for gestational age, sex and birth weight (+/- 250 g) were randomly allocated into 3 groups of 50 each, one group (Group C) being used as control. Group A received Intraglobulin (Biotest Pharma, West Germany), 120 mg/kg intravenously, within 2 to 4 hours of delivery; Group B received the same on days 1 and 8. The control group received no immunoglobulin. The frequency of infection and serum immunoglobulin concentrations were determined in each group. Infection rate in the control group was 16% (8 of 50) while in each of the treated groups it was 4% (2 of 50) (P less than 0.005). The immunoglobulin concentrations achieved in the treated group were significantly higher than the control group. No adverse effect of the therapy was noted during the study and at a 6-month follow-up. It is suggested that in nurseries where the infection rate is high, prophylactic intravenous polyvalent immunoglobulin therapy for the preterm and low birth weight infants may provide protection from infection.
K N Haque; M H Zaidi; S K Haque; H Bahakim; M el-Hazmi; M el-Swailam
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric infectious disease     Volume:  5     ISSN:  0277-9730     ISO Abbreviation:  Pediatr Infect Dis     Publication Date:    1986 Nov-Dec
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8209468     Medline TA:  Pediatr Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  622-5     Citation Subset:  IM    
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MeSH Terms
Bacterial Infections / prevention & control*
Immunization, Passive
Immunoglobulin A / analysis
Immunoglobulin G / administration & dosage,  analogs & derivatives*,  analysis,  therapeutic use
Immunoglobulin M / analysis
Immunoglobulins, Intravenous
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature, Diseases / prevention & control*
Infusions, Intravenous
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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