Document Detail

Intravenous immunoglobulin in the prevention of recurrent miscarriage. The German RSA/IVIG Group.
MedLine Citation:
PMID:  7826961     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to verify a specific effect of intravenous immunoglobulin on the outcome of pregnancy in patients with a history of recurrent miscarriage as an alternative to immunotherapy with allogeneic leucocytes. STUDY DESIGN: In a randomised double-blind multicentre study 64 patients with a history of unexplained primary recurrent miscarriage were treated with intravenous immunoglobulin (verum) or 5% human albumin (placebo) infusions during their following pregnancy. RESULTS: Success rates for both verum and placebo, were compared excluding seven patients with explained miscarriage (20/27 (74%) versus 21/30 (70%)) and without any such exclusion (20/33 (61%) versus 21/31 (68%)). The difference between the two groups was not statistically significant. CONCLUSIONS: A specific effect of intravenous immunoglobulin in primary recurrent miscarriage could not be demonstrated. These results imply the possibility of psychological influence, i.e. a placebo effect of intravenous immunoglobulin, on the outcome of pregnancy. Since success rates for both verum and placebo were in the same range as for treatment with allogeneic leucocytes, psychological effects might be responsible also for other kinds of immunotherapy for prevention of recurrent miscarriage. However, it cannot be excluded that success rates only reflect background values as reported for recurrent miscarriage patients without any treatment.
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  101     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1072-7     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Habitual / etiology,  prevention & control*
Double-Blind Method
Immunoglobulins, Intravenous / adverse effects,  therapeutic use*
Pregnancy Outcome
Reg. No./Substance:
0/Immunoglobulins, Intravenous
Comment In:
Br J Obstet Gynaecol. 1995 Jun;102(6):509-10   [PMID:  7632656 ]
Br J Obstet Gynaecol. 1995 Jun;102(6):510   [PMID:  7632657 ]

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