Document Detail


Intravenous immunoglobulin in ABO and Rh hemolytic diseases of newborn.
MedLine Citation:
PMID:  17143357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate whether the use of intravenous immunoglobulin in newborn infants with isoimmune hemolytic jaundice due to Rh and ABO incompatibility is an effective treatment in reducing the need for exchange transfusion. METHODS: This study included all direct Coombs' test positive Rh and ABO isoimmunized babies, who admitted in the Neonatal Intensive Care Unit of Ghaem Hospital of Mashhad University of Medical Sciences, Iran, from October 2003 to October 2004. Significant hyperbilirubinemia was defined as rising by >or=0.5 mg/dl per hour. Babies were randomly assigned to received phototherapy with intravenous immunoglobulin (IVIg) 0.5 g/kg over 4 hours, every 12 hours for 3 doses (study group) or phototherapy alone (control group). Exchange transfusion was performed in any group if serum bilirubin exceeded >or=20mg/dl or rose by >or=1mg/dl/h. RESULTS: A total of 34 babies were eligible for this study (17 babies in each group). The number of exchange transfusion, duration of phototherapy and hospitalization days, were significant shorter in the study group versus control group. When we analyzed the outcome results in ABO and Rh hemolytic disease separately, the efficacy of IVIg was significantly better in Rh versus ABO isoimmunization. Late anemia was more common in the IVIg group 11.8% versus 0%, p=0.48. Adverse effects were not observed during IVIg administration. CONCLUSION: Administration of IVIg to newborns with significant hyperbilirubinemia due to Rh hemolytic disease reduced the need for exchange transfusion but in ABO hemolytic disease there was no significant difference between IVIg and double surface blue light phototherapy.
Authors:
Fatemeh Nasseri; Gholam A Mamouri; Homa Babaei
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Saudi medical journal     Volume:  27     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-04-26     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1827-30     Citation Subset:  IM    
Affiliation:
Division of Neonatology, Department of Pediatrics, Mashhad University of Medical Sciences, Iran. nasseri@med.mui.ac.ir
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MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System*
Erythroblastosis, Fetal / drug therapy*
Female
Humans
Immunoglobulins, Intravenous / therapeutic use*
Immunologic Factors / therapeutic use*
Infant, Newborn
Male
Rh Isoimmunization / drug therapy*
Chemical
Reg. No./Substance:
0/ABO Blood-Group System; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors

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