Document Detail

Intravenous immunoglobulin, blood viscosity and myocardial infarction.
MedLine Citation:
PMID:  9284845     Owner:  NLM     Status:  MEDLINE    
Polyvalent intravenous immunoglobulin (IVIg) is considered to be standard therapy for a variety of autoimmune and idiopathic disorders. Several reports have emphasized the temporal association between administration of IVIg and thrombotic events. Recent experience with a patient who suffered a large myocardial infarction shortly after receiving IVIg led the authors to review the clinical and basic literature on administration of IVIg as a possible precipitant for myocardial infarction. Although the existence of an association between IVIg administration and myocardial ischemia has not been demonstrated in clinical trials, a body of clinical experience has begun to accumulate that is suggestive of an association between IVIg administration and cardiac and cerebral ischemia in older individuals or individuals with a known history of ischemic disease. Basic research demonstrating that IVIg administration may increase blood viscosity suggests that such an association is plausible.
D N Fisman; M Smilovitch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  13     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-12     Completed Date:  1997-09-12     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  775-7     Citation Subset:  IM    
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec.
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MeSH Terms
Angina Pectoris / drug therapy
Blood Viscosity / drug effects*
Chronic Disease
Demyelinating Diseases / drug therapy*
Fatal Outcome
Immunoglobulins / administration & dosage,  adverse effects*
Injections, Intravenous
Myocardial Infarction / chemically induced*
Polyneuropathies / drug therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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