| Intravenous immunoglobulin, blood viscosity and myocardial infarction. | |
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MedLine Citation:
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PMID: 9284845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polyvalent intravenous immunoglobulin (IVIg) is considered to be standard therapy for a variety of autoimmune and idiopathic disorders. Several reports have emphasized the temporal association between administration of IVIg and thrombotic events. Recent experience with a patient who suffered a large myocardial infarction shortly after receiving IVIg led the authors to review the clinical and basic literature on administration of IVIg as a possible precipitant for myocardial infarction. Although the existence of an association between IVIg administration and myocardial ischemia has not been demonstrated in clinical trials, a body of clinical experience has begun to accumulate that is suggestive of an association between IVIg administration and cardiac and cerebral ischemia in older individuals or individuals with a known history of ischemic disease. Basic research demonstrating that IVIg administration may increase blood viscosity suggests that such an association is plausible. |
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Authors:
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D N Fisman; M Smilovitch |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 13 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-12 Completed Date: 1997-09-12 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 775-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Victoria Hospital, Montreal, Quebec. dfisman@bidmc.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / drug therapy Blood Viscosity / drug effects* Chronic Disease Demyelinating Diseases / drug therapy* Fatal Outcome Humans Immunoglobulins / administration & dosage, adverse effects* Injections, Intravenous Male Myocardial Infarction / chemically induced* Polyneuropathies / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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