Document Detail

Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility.
MedLine Citation:
PMID:  18616629     Owner:  NLM     Status:  MEDLINE    
AIM: To conduct a quality control review of a single institution experience with intravenous immune globulin in the treatment of Rhesus and AB0 incompatibility. METHODS: Intravenous immune globulin as treatment for Rhesus and AB0 incompatibility was introduced in our hospital in 1998. We performed a chart review of 176 infants with Rhesus or AB0 incompatibility treated in our hospital between 1993 and 2003, divided into a historical control group (1993-1998) and a treatment group (1999-2003). The project was approved through institutional ethics procedures. RESULTS: The use of exchange transfusion as a therapeutic modality was significantly reduced in the cohort treated with intravenous immune globulin (OR 0.11; 95% CI 0.046-0.26, p < 0.001). We found no difference between the intravenous immune globulin group and the infants receiving only exchange transfusion as far as the duration of phototherapy. Infants with Rhesus incompatibility had a higher need for top-up transfusions than those with AB0 incompatibility. CONCLUSION: This study supports the evidence from previous studies suggesting that intravenous immune globulin significantly reduces the need for exchange transfusion in infants with Rhesus and AB0 incompatibility.
Kmn Huizing; J Røislien; Twr Hansen
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Publication Detail:
Type:  Journal Article     Date:  2008-07-09
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1362-5     Citation Subset:  IM    
Division of Paediatrics, Rikshospitalet University Hospital and Faculty of Medicine, University of Oslo, Norway.
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MeSH Terms
ABO Blood-Group System / blood*
Bilirubin / blood*
Blood Group Incompatibility / therapy*
Confidence Intervals
Exchange Transfusion, Whole Blood*
Immunoglobulins, Intravenous / administration & dosage,  therapeutic use*
Intensive Care Units, Neonatal
Medical Records
Odds Ratio
Quality Control*
Retrospective Studies
Rh Isoimmunization / therapy*
Time Factors
Reg. No./Substance:
0/ABO Blood-Group System; 0/Immunoglobulins, Intravenous; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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