Document Detail


Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility.
MedLine Citation:
PMID:  18616629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To conduct a quality control review of a single institution experience with intravenous immune globulin in the treatment of Rhesus and AB0 incompatibility. METHODS: Intravenous immune globulin as treatment for Rhesus and AB0 incompatibility was introduced in our hospital in 1998. We performed a chart review of 176 infants with Rhesus or AB0 incompatibility treated in our hospital between 1993 and 2003, divided into a historical control group (1993-1998) and a treatment group (1999-2003). The project was approved through institutional ethics procedures. RESULTS: The use of exchange transfusion as a therapeutic modality was significantly reduced in the cohort treated with intravenous immune globulin (OR 0.11; 95% CI 0.046-0.26, p < 0.001). We found no difference between the intravenous immune globulin group and the infants receiving only exchange transfusion as far as the duration of phototherapy. Infants with Rhesus incompatibility had a higher need for top-up transfusions than those with AB0 incompatibility. CONCLUSION: This study supports the evidence from previous studies suggesting that intravenous immune globulin significantly reduces the need for exchange transfusion in infants with Rhesus and AB0 incompatibility.
Authors:
Kmn Huizing; J Røislien; Twr Hansen
Related Documents :
9241889 - Trends in neonatal exchange transfusions at yodogawa christian hospital.
9581299 - Incidence of thrombocytopenia in infants born to mothers with idiopathic thrombocytopen...
13316529 - Management of erythroblastosis fetalis.
21082539 - Type and timing of ventilation in the first postnatal week is associated with bronchopu...
12969869 - Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics ...
21292699 - Brain death revisited: it is not 'complete death' according to islamic sources.
11518589 - Volunteer-based universal newborn hearing screening program.
3141649 - Gastric pepsin and acid secretion during total parenteral nutrition and constant-rate e...
8545169 - Efficacy of surfactant therapy in infants managed with cpap.
Publication Detail:
Type:  Journal Article     Date:  2008-07-09
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1362-5     Citation Subset:  IM    
Affiliation:
Division of Paediatrics, Rikshospitalet University Hospital and Faculty of Medicine, University of Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System / blood*
Bilirubin / blood*
Blood Group Incompatibility / therapy*
Confidence Intervals
Exchange Transfusion, Whole Blood*
Humans
Immunoglobulins, Intravenous / administration & dosage,  therapeutic use*
Intensive Care Units, Neonatal
Medical Records
Norway
Odds Ratio
Phototherapy
Quality Control*
Retrospective Studies
Rh Isoimmunization / therapy*
Time Factors
Chemical
Reg. No./Substance:
0/ABO Blood-Group System; 0/Immunoglobulins, Intravenous; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diagnosis on a positive fashion of nonorganic failure to thrive.
Next Document:  Male circumcision through the ages: the role of tradition.