| Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility. | |
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MedLine Citation:
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PMID: 18616629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To conduct a quality control review of a single institution experience with intravenous immune globulin in the treatment of Rhesus and AB0 incompatibility. METHODS: Intravenous immune globulin as treatment for Rhesus and AB0 incompatibility was introduced in our hospital in 1998. We performed a chart review of 176 infants with Rhesus or AB0 incompatibility treated in our hospital between 1993 and 2003, divided into a historical control group (1993-1998) and a treatment group (1999-2003). The project was approved through institutional ethics procedures. RESULTS: The use of exchange transfusion as a therapeutic modality was significantly reduced in the cohort treated with intravenous immune globulin (OR 0.11; 95% CI 0.046-0.26, p < 0.001). We found no difference between the intravenous immune globulin group and the infants receiving only exchange transfusion as far as the duration of phototherapy. Infants with Rhesus incompatibility had a higher need for top-up transfusions than those with AB0 incompatibility. CONCLUSION: This study supports the evidence from previous studies suggesting that intravenous immune globulin significantly reduces the need for exchange transfusion in infants with Rhesus and AB0 incompatibility. |
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Authors:
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Kmn Huizing; J Røislien; Twr Hansen |
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Publication Detail:
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Type: Journal Article Date: 2008-07-09 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 97 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1362-5 Citation Subset: IM |
Affiliation:
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Division of Paediatrics, Rikshospitalet University Hospital and Faculty of Medicine, University of Oslo, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System
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blood* Bilirubin / blood* Blood Group Incompatibility / therapy* Confidence Intervals Exchange Transfusion, Whole Blood* Humans Immunoglobulins, Intravenous / administration & dosage, therapeutic use* Intensive Care Units, Neonatal Medical Records Norway Odds Ratio Phototherapy Quality Control* Retrospective Studies Rh Isoimmunization / therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System; 0/Immunoglobulins, Intravenous; 635-65-4/Bilirubin |
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