Document Detail


Intravenous histamine administration in ponies with recurrent airway obstruction (heaves).
MedLine Citation:
PMID:  4014826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary function and airway reactivity to IV histamine were measured in a group of ponies with a history of recurrent airway obstruction (heaves) and their age-, weight-, and gender-matched controls. Ponies were studied during a period of clinical remission (period A), after exposure to a barn environment (period B), and twice during a 2-week recovery phase (periods C and D). At periods A, C, and D, PaO2, dynamic compliance (Cdyn), pulmonary resistance, tidal volume, respiratory frequency, and the log dose of histamine required to reduce Cdyn to 65% of base-line value (log ED65Cdyn) of principals and controls did not differ. Barn exposure (period B) decreased Cdyn, PaO2, and ED65Cdyn and increased pulmonary resistance in principals but not controls. The slope of the histamine dose-Cdyn response curves was not different between principal and control groups of ponies and was unaffected by barn exposure or return to pasture. There was a poor correlation between ED65Cdyn and indices of airway caliber. During acute airway obstruction, ponies with a history of heaves were hyperreactive to IV histamine, but during disease remission, airway response to histamine was not different from that of control ponies. Seemingly, hyperreactivity in principal ponies after exposure to a barn environment cannot be explained solely by alterations in base-line airway caliber.
Authors:
F J Derksen; D Scott; N E Robinson; R F Slocombe; P J Armstrong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of veterinary research     Volume:  46     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-08-05     Completed Date:  1985-08-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  774-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Airway Obstruction / physiopathology,  veterinary*
Animals
Dose-Response Relationship, Drug
Histamine / administration & dosage,  pharmacology*
Horse Diseases / physiopathology*
Horses
Lung / drug effects*,  physiopathology
Recurrence
Respiratory Function Tests / veterinary
Grant Support
ID/Acronym/Agency:
HL27619/HL/NHLBI NIH HHS; HL30669/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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