Document Detail

Intravenous flunitrazepam for status epilepticus.
MedLine Citation:
PMID:  2515734     Owner:  NLM     Status:  MEDLINE    
Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus. Case 1 was a patient with a tonic-clonic status epilepticus. Intravenous phenytoin had no effect. Case 2 had minor status epilepticus. With the intravenous administration of FZP, diluted 1:10 with distilled water at a dose of 0.03 mg/kg at a slow rate, both patients were relieved of the status epilepticus. Unlike diazepam, FZP neither looks cloudy when diluted with distilled water nor causes angialgia. No disturbances in circulation or respiration occurred. Considering that FZP has a strong anticonvulsant action on status epilepticus, it can be expected to be a useful therapeutic agent for status epilepticus in infants and children.
K Sumi; T Nagaura; N Sakata; T Nishigaki; M Akagi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  31     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-09     Completed Date:  1990-03-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  563-6     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Flunitrazepam / administration & dosage*
Injections, Intravenous
Status Epilepticus / drug therapy*
Reg. No./Substance:

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