| Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia. | |
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MedLine Citation:
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PMID: 19583070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prolongation of spinal anesthesia by using clonidine through the oral, intravenous and spinal route has been known. The new alpha 2 agonist, dexmedetomidine has been proved to prolong the spinal anesthesia through the intrathecal route. We hypothesized that dexmedetomidine when administered intravenously following spinal block, also prolongs spinal analgesia. METHODS: 48 patients were randomly allocated into two equal groups following receiving spinal isobaric bupivacaine 12.5 mg. Patients in group D received intravenously a loading dose of 1 microg/kg dexmedetomidine over 10 min and a maintenance dose of 0.5 microg/kg/hr. Patients in group C (the control group) received normal saline. The regression times to reach S1 sensory level and Bromage 0 motor scale, hemodynamic changes and the level of sedation were recorded. RESULTS: The duration of sensory block was longer in intravenous dexmedetomidine group compared with control group (261.5 +/- 34.8 min versus 165.2 +/- 31.5 min, P < 0.05). The duration of motor block was longer in dexmedetomidine group than control group (199 +/- 42.8 min versus 138.4 +/- 31.3 min, P < 0.05). CONCLUSION: Intravenous dexmedetomidine administration prolonged the sensory and motor blocks of bupivacaine spinal analgesia with good sedation effect and hemodynamic stability. |
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Authors:
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Mahmoud M Al-Mustafa; Izdiad Z Badran; Hamdi M Abu-Ali; Bassam A Al-Barazangi; Isalm M Massad; Subhi M Al-Ghanem |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Middle East journal of anesthesiology Volume: 20 ISSN: 0544-0440 ISO Abbreviation: Middle East J Anesthesiol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-08 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8604187 Medline TA: Middle East J Anesthesiol Country: Lebanon |
Other Details:
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Languages: eng Pagination: 225-31 Citation Subset: IM |
Affiliation:
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Dept. of Anesthesia & Intensive Care, Faculty of Medicine, Univ. of Jordan, Amman, Jordan. mahmoud_juh@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Aged Anesthesia, Spinal / methods Anesthetics, Local / administration & dosage, pharmacology* Bupivacaine / administration & dosage, pharmacology* Dexmedetomidine / pharmacology* Female Hemodynamics / drug effects Humans Infusions, Intravenous Male Middle Aged Nerve Block / methods Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Anesthetics, Local; 113775-47-6/Dexmedetomidine; 2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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