Document Detail

Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia.
MedLine Citation:
PMID:  19583070     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The prolongation of spinal anesthesia by using clonidine through the oral, intravenous and spinal route has been known. The new alpha 2 agonist, dexmedetomidine has been proved to prolong the spinal anesthesia through the intrathecal route. We hypothesized that dexmedetomidine when administered intravenously following spinal block, also prolongs spinal analgesia.
METHODS: 48 patients were randomly allocated into two equal groups following receiving spinal isobaric bupivacaine 12.5 mg. Patients in group D received intravenously a loading dose of 1 microg/kg dexmedetomidine over 10 min and a maintenance dose of 0.5 microg/kg/hr. Patients in group C (the control group) received normal saline. The regression times to reach S1 sensory level and Bromage 0 motor scale, hemodynamic changes and the level of sedation were recorded.
RESULTS: The duration of sensory block was longer in intravenous dexmedetomidine group compared with control group (261.5 +/- 34.8 min versus 165.2 +/- 31.5 min, P < 0.05). The duration of motor block was longer in dexmedetomidine group than control group (199 +/- 42.8 min versus 138.4 +/- 31.3 min, P < 0.05).
CONCLUSION: Intravenous dexmedetomidine administration prolonged the sensory and motor blocks of bupivacaine spinal analgesia with good sedation effect and hemodynamic stability.
Mahmoud M Al-Mustafa; Izdiad Z Badran; Hamdi M Abu-Ali; Bassam A Al-Barazangi; Isalm M Massad; Subhi M Al-Ghanem
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  20     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-08-04     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Anesthesia, Spinal / methods
Anesthetics, Local / administration & dosage,  pharmacology*
Bupivacaine / administration & dosage,  pharmacology*
Dexmedetomidine / pharmacology*
Hemodynamics / drug effects
Infusions, Intravenous
Middle Aged
Nerve Block / methods
Time Factors
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Local; 67VB76HONO/Dexmedetomidine; Y8335394RO/Bupivacaine

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