Document Detail


Intravenous cyclophosphamide therapy in a case with refractory thrombotic microangiopathic hemolytic anemia and SLE.
MedLine Citation:
PMID:  15801075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The case of a 27-year-old woman who simultaneously presented with SLE and severe refractory thrombotic microangiopathic hemolytic anemia (TMHA) is reported. She had extremely high levels of platelet-associated IgG (PAIgG), and her TMHA was refractory to plasma exchange and corticosteroid therapy. However, the TMHA was effectively controlled by i.v. cyclophosphamide therapy. ITP and TTP are generally considered distinct diseases; however, TMHA may occur secondary to platelet aggregation via autoimmune mechanisms in certain cases. Immunosuppressive therapy at an early stage of the disease may be beneficial in refractory cases of TMHA with autoimmune features.
Authors:
Jun Akaogi; Noriko Akasaka; Hidehiro Yamada; Nobuaki Hama; Minoru Satoh; Cody Nichols; Shoichi Ozaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  23     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-03-31     Completed Date:  2005-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  541-3     Citation Subset:  IM    
Affiliation:
Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan. j2akaogi@marianna-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Hemolytic / complications,  drug therapy*,  immunology
Antirheumatic Agents / administration & dosage*
Cyclophosphamide / administration & dosage*
Female
Humans
Infusions, Intravenous
Lupus Erythematosus, Systemic / complications*,  immunology
Thrombosis / etiology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 50-18-0/Cyclophosphamide

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