| Intravenous cyclophosphamide therapy in a case with refractory thrombotic microangiopathic hemolytic anemia and SLE. | |
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MedLine Citation:
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PMID: 15801075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case of a 27-year-old woman who simultaneously presented with SLE and severe refractory thrombotic microangiopathic hemolytic anemia (TMHA) is reported. She had extremely high levels of platelet-associated IgG (PAIgG), and her TMHA was refractory to plasma exchange and corticosteroid therapy. However, the TMHA was effectively controlled by i.v. cyclophosphamide therapy. ITP and TTP are generally considered distinct diseases; however, TMHA may occur secondary to platelet aggregation via autoimmune mechanisms in certain cases. Immunosuppressive therapy at an early stage of the disease may be beneficial in refractory cases of TMHA with autoimmune features. |
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Authors:
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Jun Akaogi; Noriko Akasaka; Hidehiro Yamada; Nobuaki Hama; Minoru Satoh; Cody Nichols; Shoichi Ozaki |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical rheumatology Volume: 23 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-03-31 Completed Date: 2005-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Belgium |
Other Details:
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Languages: eng Pagination: 541-3 Citation Subset: IM |
Affiliation:
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Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan. j2akaogi@marianna-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Hemolytic / complications, drug therapy*, immunology Antirheumatic Agents / administration & dosage* Cyclophosphamide / administration & dosage* Female Humans Infusions, Intravenous Lupus Erythematosus, Systemic / complications*, immunology Thrombosis / etiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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