Document Detail


Intravenous clonidine hydrochloride toxicity in pregnant ewes.
MedLine Citation:
PMID:  2916635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of intravenous clonidine hydrochloride has been advocated to rapidly control blood pressure in severe preeclampsia. To examine clonidine's acute maternal and fetal effects were intravenously injected 300 micrograms clonidine in eight chronically prepared normotensive near term ewes. Unlike intravenous saline solution injection, clonidine produced significant toxicity--intraamniotic pressure increased 97 +/- 27% (p less than 0.05), uterine blood flow decreased 55 +/- 7% (p less than 0.001), maternal and fetal serum glucose increased 158 +/- 23% and 249 +/- 91%, respectively (p less than 0.001), and maternal and fetal Po2 decreased to 44 mm Hg +/- 4 mm Hg and 13 mm Hg +/- 1 mm Hg, respectively (p less than 0.05). Maternal and fetal blood pressure and serum cortisol were unaffected by clonidine, whereas heart rate decreased. No adverse maternal or fetal effects were noted with serum clonidine concentrations less than 1.0 ng/ml. Direct fetal infusion of clonidine did not lower fetal arterial Po2 levels, although heart rates decreased and serum glucose levels increased. The multiple effects of clonidine infusion are best explained by actions on alpha 2-adrenergic receptors. These results suggest that intravenous administration of clonidine may adversely affect the fetus by direct actions and by alterations in maternal physiology.
Authors:
J C Eisenach; M I Castro; D M Dewan; J C Rose; S C Grice
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  160     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Clonidine / administration & dosage,  pharmacokinetics,  toxicity*
Female
Fetal Blood / analysis
Heart Rate / drug effects
Heart Rate, Fetal / drug effects
Hydrocortisone / blood
Injections, Intravenous
Oxygen / blood
Pregnancy
Pregnancy, Animal / blood,  drug effects*,  physiology
Regional Blood Flow / drug effects
Sheep
Uterus / blood supply,  drug effects
Grant Support
ID/Acronym/Agency:
GM 35523/GM/NIGMS NIH HHS; R01 HD017644/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; MN3L5RMN02/Clonidine; S88TT14065/Oxygen; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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