Document Detail

Intravenous chlorpromazine for the emergency treatment of uncontrolled symptomatic hypertension in the pre-hospital setting: data from 500 consecutive cases.
MedLine Citation:
PMID:  16382707     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chlorpromazine is a dopamine-receptor antagonist antipsychotic agent. Because of its strong alpha-blocking and sedative actions, it has also been used as emergency therapy for extreme arterial hypertension. Published reports to date have included very small numbers of patients (i.e., 5-30). OBJECTIVES: To analyze data on almost 500 patients who received intravenous chlorpromazine for the emergency treatment of uncontrolled symptomatic hypertension in the pre-hospital setting. METHODS: We reviewed data from 496 consecutive patients who received intravenous chlorpromazine as emergency therapy for uncontrolled symptomatic hypertension. Chlorpromazine was injected intravenously. The dose was 1 mg every 2-5 minutes until the systolic pressure was < or =140 mmHg and the diastolic pressure < or =100 mmHg with alleviation of symptoms. RESULTS: The mean dose of chlorpromazine administered was 4.5 +/- 5 mg (range 1-50 mg). Only 33 patients (7%) required >10 mg. Chlorpromazine reduced systolic BP from 222.82 +/- 26.31 to 164.93 +/- 22.66 mmHg (P< 0.001) and diastolic BP from 113.5 +/-16.63 to 85.83 +/- 11.61 mmHg (P< 0.001). The sinus rate decreased from 97.9 +/- 23.5 to 92.2 +/- 19.7 beats per minute (P< 0.001). These results were achieved within the first 37 +/- 11 minutes. CONCLUSIONS: Intravenous chlorpromazine is safe and effective when used as emergency treatment for uncontrolled symptomatic hypertension.
Sami Viskin; Michael Berger; Maya Ish-Shalom; Nomi Malov; Mira Tamari; Michal Golovner; Meyara Kehati; David Zeltser; Arie Roth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  7     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-30     Completed Date:  2006-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  812-5     Citation Subset:  IM    
Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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MeSH Terms
Antipsychotic Agents / administration & dosage,  therapeutic use*
Blood Pressure / drug effects
Chlorpromazine / administration & dosage,  therapeutic use*
Emergency Medical Services / statistics & numerical data*
Hypertension / drug therapy*,  physiopathology
Injections, Intravenous
Retrospective Studies
Reg. No./Substance:
0/Antipsychotic Agents; 50-53-3/Chlorpromazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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