Document Detail

Intravenous amiodarone vs propafenone for atrial fibrillation and flutter after cardiac operation.
MedLine Citation:
PMID:  8562105     Owner:  NLM     Status:  MEDLINE    
The safety and efficacy of amiodarone and propafenone in converting atrial fibrillation or flutter after cardiac surgery were compared in a randomized double-blind trial. Eighty-four patients with sustained atrial tachyarrhythmias of more than 30 min' duration, stable hemodynamic status and neither preoperative atrial arrhythmias nor treatment with other antiarrhythmis drugs, were randomized to receive amiodarone (46 patients: 5 mg/kg over 15 min and then 15 mg/kg over the subsequent 24 h for non-converting) or propafenone (38 patients: 2 mg/kg over 15 in and then 10 mg/kg over the subsequent 24 h for non-converting). Nine of the 46 patients (19.5%) receiving amiodarone converted to sinus rhythm within 1 h following bolus injection compared with 17 of 38 patients (44.7%) treated with propafenone (P < 0.05). Within the 24 h study, 38 of 46 patients (82.6%) given amiodarone and 26 of 38 patients (68.4%) given propafenone were converted to sinus rhythm (P = NS). A significantly progressive reduction in ventricular response, already evident at 10th min from the start of treatment, was achieved in both groups of patients. Side effects occurred in six patients given propafenone (15.7%) and in five given amiodarone (10.8%) (P = NS). The two drugs were equally effective in converting postoperative atrial fibrillation and/or flutter after 24 h although propafenone was superior within the first hour.
P Di Biasi; R Scrofani; A Paje; E Cappiello; A Mangini; C Santoli
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  9     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-07     Completed Date:  1996-03-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM    
Divisione di Chirurgia Toracia e Cardiovascolare, Osp. L. Sacco, Milano, Italy.
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MeSH Terms
Amiodarone / administration & dosage*,  adverse effects
Anti-Arrhythmia Agents / administration & dosage*,  adverse effects
Atrial Fibrillation / drug therapy*
Atrial Flutter / drug therapy*
Coronary Disease / surgery*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Electrocardiography, Ambulatory / drug effects
Heart Valve Diseases / surgery*
Hemodynamics / drug effects
Infusions, Intravenous
Middle Aged
Postoperative Complications / drug therapy*
Propafenone / administration & dosage*,  adverse effects
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 54063-53-5/Propafenone
Comment In:
Eur J Cardiothorac Surg. 1996;10(12):1144-6   [PMID:  10369653 ]

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