| Intravenous amiodarone vs propafenone for atrial fibrillation and flutter after cardiac operation. | |
MedLine Citation:
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PMID: 8562105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The safety and efficacy of amiodarone and propafenone in converting atrial fibrillation or flutter after cardiac surgery were compared in a randomized double-blind trial. Eighty-four patients with sustained atrial tachyarrhythmias of more than 30 min' duration, stable hemodynamic status and neither preoperative atrial arrhythmias nor treatment with other antiarrhythmis drugs, were randomized to receive amiodarone (46 patients: 5 mg/kg over 15 min and then 15 mg/kg over the subsequent 24 h for non-converting) or propafenone (38 patients: 2 mg/kg over 15 in and then 10 mg/kg over the subsequent 24 h for non-converting). Nine of the 46 patients (19.5%) receiving amiodarone converted to sinus rhythm within 1 h following bolus injection compared with 17 of 38 patients (44.7%) treated with propafenone (P < 0.05). Within the 24 h study, 38 of 46 patients (82.6%) given amiodarone and 26 of 38 patients (68.4%) given propafenone were converted to sinus rhythm (P = NS). A significantly progressive reduction in ventricular response, already evident at 10th min from the start of treatment, was achieved in both groups of patients. Side effects occurred in six patients given propafenone (15.7%) and in five given amiodarone (10.8%) (P = NS). The two drugs were equally effective in converting postoperative atrial fibrillation and/or flutter after 24 h although propafenone was superior within the first hour. |
Authors:
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P Di Biasi; R Scrofani; A Paje; E Cappiello; A Mangini; C Santoli |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: 9 ISSN: 1010-7940 ISO Abbreviation: Eur J Cardiothorac Surg Publication Date: 1995 |
Date Detail:
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Created Date: 1996-03-07 Completed Date: 1996-03-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 587-91 Citation Subset: IM |
Affiliation:
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Divisione di Chirurgia Toracia e Cardiovascolare, Osp. L. Sacco, Milano, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / administration & dosage*, adverse effects Anti-Arrhythmia Agents / administration & dosage*, adverse effects Atrial Fibrillation / drug therapy* Atrial Flutter / drug therapy* Coronary Disease / surgery* Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Electrocardiography, Ambulatory / drug effects Female Heart Valve Diseases / surgery* Hemodynamics / drug effects Humans Infusions, Intravenous Male Middle Aged Postoperative Complications / drug therapy* Propafenone / administration & dosage*, adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 54063-53-5/Propafenone |
| Comments/Corrections | |
Comment In:
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Eur J Cardiothorac Surg. 1996;10(12):1144-6
[PMID:
10369653
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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