Document Detail

Intravenous administration of human IgG to newborn infants: changes in serum antibody levels to group B streptococci.
MedLine Citation:
PMID:  6394336     Owner:  NLM     Status:  MEDLINE    
A human IgG preparation was given intravenously to 36 newborn infants admitted to the neonatal intensive care unit because of suspected septicaemia. IgG was given as a single dose of 0.4 g/kg body weight. Patient serum was obtained immediately before and 30 min after terminating the infusion. Blood was also withdrawn 2 days after giving the IgG in eight of the infants. The sera were tested by radioimmunoassay for IgG antibody levels to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III and to R-protein. The mean increases in anti-type Ia, Ib, II, III and R-protein antibodies 30 min after the end of infusion were 81%, 73%, 49%, 60% and 69% of the preinfusion levels, respectively. This was followed by a rapid decrease during the following 2 days to 25%-32% of the initial increases. Based on the above findings, a controlled trial of passive immunisation in the management of neonatal GBS septicaemia seems justified. The rapid decline in antibody levels would necessitate a second infusion 24 h after the initial immunoglobulin administration if the suspicion of septicaemia persists.
K K Christensen; P Christensen; H U Bucher; G Duc; C H Kind; D Mieth; B Müller; R A Seger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pediatrics     Volume:  143     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
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MeSH Terms
Antibodies, Bacterial / analysis*
Antibody Specificity
Immunoglobulin G / administration & dosage*
Infant, Newborn
Infusions, Parenteral
Sepsis / therapy*
Streptococcal Infections / therapy*
Streptococcus agalactiae / immunology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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