| Intravenous administration of bone marrow mesenchymal stem cells benefits experimental autoimmune myasthenia gravis mice through an immunomodulatory action. | |
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MedLine Citation:
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PMID: 20696022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mesenchymal stem cells (MSC) are potent in immunomodulation. It has been proven that MSC functioned to correct immune disorder in several immune diseases. Here, we tested the hypothesis that MSC from human bone marrow (hMSC) can provide a potential therapy for experimental autoimmune myasthenia gravis (EAMG). EAMG mice model was established by subcutaneous injection of synthetic analogue of acetylcholine receptor (AchR), then, hMSC were intravenously delivered into these mice repeatedly. The results showed that hMSC could specifically home to spleen tissue and hMSC treatment significantly improved the functional deficits of EAMG mice. In addition, AchR antibody level was dramatically decreased in cell-treated group when compared with untreated control on 10 days after the second cell injection. Moreover, both in vivo and in vitro mixed lymphocyte proliferation assays revealed that hMSC could definitely inhibit the proliferation of AchR-specific lymphocyte. In conclusion, our study demonstrated that hMSC treatment was therapeutically useful in autoimmune myasthenia gravis mice, and the underlying mechanism may relate with their immunomodulatory potential. |
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Authors:
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J Yu; C Zheng; X Ren; J Li; M Liu; L Zhang; L Liang; W Du; Z Chao Han |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 72 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 242-9 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Experimental Hematology, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union, Medical College (CAMS&PUMC), Tianjin, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / blood, immunology Antigens, CD / metabolism Body Weight Bone Marrow Cells / cytology* Cell Adhesion / immunology Cell Differentiation / drug effects Cell Lineage Cell Proliferation / drug effects Coculture Techniques Concanavalin A / pharmacology Culture Media, Conditioned / pharmacology Epitopes, T-Lymphocyte / immunology, pharmacology Female Humans Immunomodulation* Immunophenotyping Injections, Intravenous Leukocytes, Mononuclear / cytology, drug effects, immunology Lymphocyte Activation / immunology Lymphoid Tissue / cytology Mesenchymal Stem Cell Transplantation / methods* Mesenchymal Stem Cells / cytology*, drug effects, metabolism Mice Mice, Inbred C57BL Myasthenia Gravis, Autoimmune, Experimental / diagnosis, immunology, therapy* Receptors, Cholinergic / immunology Spleen / cytology Transplantation, Heterologous Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, CD; 0/Culture Media, Conditioned; 0/Epitopes, T-Lymphocyte; 0/Receptors, Cholinergic; 11028-71-0/Concanavalin A |
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