Document Detail

Intravenous administration of atriopeptin III affects arterial blood pressure differentially in young and old male rats.
MedLine Citation:
PMID:  2954429     Owner:  NLM     Status:  MEDLINE    
The effects of intravenous administration of various doses of atriopeptin III (0.4-36 nmol kg-1) on arterial blood pressure, urinary flow and Na+ and K+ excretion were analysed in awake animals. A dose-related reduction of arterial blood pressure was obtained in 4- and 24-month-old unrestrained, freely moving male rats. A dose-related increase in the diuresis and in sodium and potassium excretion was present in both young and old rats. The hypotensive action was significantly prolonged in the aged animals, indicating possible alterations in the control of the cardiovascular system by the endocrine activity of the heart in the old animal.
R Grimaldi; I Zini; F Agnati; K Fuxe; A Härfstrand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  129     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-8     Citation Subset:  IM    
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MeSH Terms
Aging / metabolism,  physiology*
Atrial Natriuretic Factor / administration & dosage*
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Injections, Intravenous
Potassium / urine
Rats, Inbred Strains
Sodium / urine
Urination / drug effects
Reg. No./Substance:
7440-09-7/Potassium; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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