Document Detail

Intravenous Thrombolysis Outcomes in Patients Presenting with Large Vessel Acute Ischemic Strokes-CT Angiography-Based Prognosis.
MedLine Citation:
PMID:  24888428     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: To establish outcome rates for patients receiving intravenous thrombolysis based on vascular occlusion site.
METHODS: This is a retrospective analysis of 225 patients who had received intravenous-rt-PA for anterior circulation strokes. The occlusion-site was prospectively determined on the admission computed tomographic angiography (CTA) and divided into: large vessel occlusion (LVO) including patients with an internal carotid artery terminus or middle cerebral artery (M1/proximal M2) occlusions and no large vessel occlusion (No-LVO; distal M2/M3/ACA) including patients with either distal or no occlusions. The primary outcome was the modified Rankin score (mRS) at 90-days with a good outcome defined by mRS of 0-2.000.
RESULTS: There were 114 (50.7%) patients in the LVO and 111 (49.3%) in the No-LVO group. A good outcome was seen in 28 (24.6%) patients in the LVO and 77 (69.4%) patients in the No-LVO group (OR .14; 95% CI: .08-.26; P < .0001). Mortality was observed in 13 (11.7%) patients in the No-LVO group and 48 (42.1%) patients in the LVO group (OR .18; 95% CI: .09-.36; P < .0001). Significant hemorrhage was seen in 14 (12.5%) patients in the LVO and 0 (0%) patients in the No-LVO group (P < .0001). Older age (OR .96; 95% CI: .93-.98; P = .002) and presence of LVO (OR .29; 95% CI: .12-.68; P = .004) were significant independent predictors of poor outcome.
CONCLUSION: CTA identification of proximal occlusions is associated with significantly poor outcomes in patients receiving intravenous stroke thrombolysis.
Ansaar Rai; Brendan Cline; Eric Williams; Jeffrey Carpenter; Thomas Roberts
Related Documents :
24055018 - Plasma level of neopterin as a marker of disease activity in treated rheumatoid arthrit...
23881468 - The complement and immunoglobulin levels in nmo patients.
23329358 - A prospective evaluation of changes in brain structure and cognitive functions in adult...
24298388 - Anal involvement in pemphigus vularis.
24055018 - Plasma level of neopterin as a marker of disease activity in treated rheumatoid arthrit...
15646288 - Complete cleft lip and palate without bone grafting and its effect on craniofacial morp...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-3
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  -     ISSN:  1552-6569     ISO Abbreviation:  J Neuroimaging     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 by the American Society of Neuroimaging.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low birthweight and elevated levels of lipoprotein(a) in prepubertal children.
Next Document:  Physical Ischemia Induced by Isometric Exercise Facilitated Collateral Development in the Remote Isc...