| Intravenous Paracetamol Treatment in the Management of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants. | |
| | |
MedLine Citation:
|
PMID: 23258386 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Treatment options for the closure of a hemodynamically significant patent ductus arteriosus (hsPDA) include medical therapy such as ibuprofen and indomethacin and surgical ligation. Objective: To evaluate the efficacy of intravenous paracetamol in preterm infants with hsPDA whose feeding was contraindicated or had feeding intolerance. Methods: Preterm infants with hsPDA were started on intravenous paracetamol treatment with parental consent. Paracetamol was administered at a dose of 60 mg/kg/day, in four divided doses, for a period of 3 days. In the absence of closure of hsPDA, treatment was extended up to 6 days, after which echocardiographic examination was performed. Results: A total of 10 preterm infants were included in the study with a median gestational age of 27(4/7) weeks (minimum-maximum: 24-29) and a median birth weight of 775 g (590-990). The first dose of intravenous paracetamol was given after a median of 6 days (2-15). On echocardiographic examination, median internal ductal diameter was 2 mm (1.5-3), with a median left atrium-to-aortic root ratio of 1.95 (1.6-2.2). Intravenous paracetamol resulted in successful closure of hsPDA in all patients. Conclusions: This study is the first case series in the literature which used intravenous paracetamol treatment for hsPDA. We believe that intravenous paracetamol could be used as an alternative drug for infants. Further prospective randomized-controlled trials are needed to evaluate the efficacy of intravenous paracetamol for the closure of hsPDA. |
| | |
Authors:
|
Mehmet Yekta Oncel; Sadik Yurttutan; Halil Degirmencioglu; Nurdan Uras; Nahide Altug; Omer Erdeve; Ugur Dilmen |
Related Documents
:
|
9505966 - Mother-to-infant transmission occurs more frequently with gb virus c than hepatitis c v... 7913986 - Recommendations of the u.s. public health service task force on the use of zidovudine t... 5337836 - Influence of the intestinal flora on the development of immune reactions in infants. 23403266 - Early neurophysiology and mri in predicting neurological outcome at 9-10years after bir... 20815706 - Intracranial volume and whole brain volume in infants with unicoronal craniosynostosis. 18978516 - The role of candida surveillance cultures for identification of a preterm subpopulation... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-19 |
Journal Detail:
|
Title: Neonatology Volume: 103 ISSN: 1661-7819 ISO Abbreviation: Neonatology Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101286577 Medline TA: Neonatology Country: - |
Other Details:
|
Languages: ENG Pagination: 165-168 Citation Subset: - |
Copyright Information:
|
Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
|
Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coordination self-assembly of tetranuclear Pt(ii) macrocycles with an organometallic backbone for se...
Next Document: New Infectious Etiologies for Posterior Uveitis.