Document Detail

Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants.
MedLine Citation:
PMID:  23258386     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Treatment options for the closure of a hemodynamically significant patent ductus arteriosus (hsPDA) include medical therapy such as ibuprofen and indomethacin and surgical ligation.
OBJECTIVE: To evaluate the efficacy of intravenous paracetamol in preterm infants with hsPDA whose feeding was contraindicated or had feeding intolerance.
METHODS: Preterm infants with hsPDA were started on intravenous paracetamol treatment with parental consent. Paracetamol was administered at a dose of 60 mg/kg/day, in four divided doses, for a period of 3 days. In the absence of closure of hsPDA, treatment was extended up to 6 days, after which echocardiographic examination was performed.
RESULTS: A total of 10 preterm infants were included in the study with a median gestational age of 27(4/7) weeks (minimum-maximum: 24-29) and a median birth weight of 775 g (590-990). The first dose of intravenous paracetamol was given after a median of 6 days (2-15). On echocardiographic examination, median internal ductal diameter was 2 mm (1.5-3), with a median left atrium-to-aortic root ratio of 1.95 (1.6-2.2). Intravenous paracetamol resulted in successful closure of hsPDA in all patients.
CONCLUSIONS: This study is the first case series in the literature which used intravenous paracetamol treatment for hsPDA. We believe that intravenous paracetamol could be used as an alternative drug for infants. Further prospective randomized-controlled trials are needed to evaluate the efficacy of intravenous paracetamol for the closure of hsPDA.
Mehmet Yekta Oncel; Sadik Yurttutan; Halil Degirmencioglu; Nurdan Uras; Nahide Altug; Omer Erdeve; Ugur Dilmen
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Publication Detail:
Type:  Journal Article     Date:  2012-12-19
Journal Detail:
Title:  Neonatology     Volume:  103     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-03     Completed Date:  2013-08-08     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  166-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Acetaminophen / administration & dosage*,  blood
Cardiovascular Agents / administration & dosage*,  blood
Chi-Square Distribution
Drug Administration Schedule
Ductus Arteriosus, Patent / drug therapy*,  ultrasonography
Gestational Age
Infant, Low Birth Weight*
Infant, Newborn
Injections, Intravenous
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Cardiovascular Agents; 362O9ITL9D/Acetaminophen
Comment In:
Neonatology. 2013;104(3):170   [PMID:  23921567 ]
Neonatology. 2013;104(1):6-7   [PMID:  23548678 ]
Neonatology. 2013;104(3):168-9   [PMID:  23921529 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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