Document Detail

Intravenous iron in heart failure: beyond targeting anemia.
MedLine Citation:
PMID:  21057903     Owner:  NLM     Status:  In-Data-Review    
Iron deficiency is commonly seen in congestive heart failure (CHF) in both anemic and nonanemic patients. In six studies in which these iron-deficient patients with CHF were treated with intravenous (IV) iron, five found an improvement in the hemoglobin. In uncontrolled and controlled studies, the New York Heart Association (NYHA) class, quality of life, and exercise capacity were improved consistently with IV iron. In some studies, cardiac function also was improved. In one large, double-blind, placebo-controlled study of IV iron, the patient global assessment, quality of life, and NYHA class improved rapidly in both those who were anemic or not anemic. In contrast to these studies, another controlled study of anemia in CHF showed no effect of oral iron on hemoglobin or on any cardiac parameters over 1 year. These studies suggest that CHF in both anemic and nonanemic iron-deficient patients may benefit from a course of IV iron, but not oral iron.
Donald S Silverberg; Adrian Iaina; Doron Schwartz; Dov Wexler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current heart failure reports     Volume:  8     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-21     Citation Subset:  IM    
Department of Nephrology, Tel Aviv Sourasky Medical Center, Weizman 6, Tel Aviv, 64239, Israel,
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