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Intravenous Iron Supplementation in Distance Runners with Low or Suboptimal Ferritin.
MedLine Citation:
PMID:  23872938     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Iron deficiency is prevalent in distance runners and may impair endurance performance. Current practice of oral supplementation is slow and often not well tolerated. The aim of this study was to assess the efficacy of intravenous iron supplementation (ferric carboxymaltose) compared to oral supplementation (ferrous sulphate) on iron status, haemoglobin mass (Hbmass) and physiological indices of running performance in distance runners.
METHODS: 27 highly-trained distance runners with low (LOW) (ferritin <35μg.L and transferrin saturation <20%, or ferritin <15μg.L) or sub optimal (SUB) iron status (ferritin <65μg.L) were supplemented with either intravenous (IV) iron (Ferinject®) or oral (ORAL) supplements (Ferrogradumet) for 6 weeks. Iron status and Hbmass were assessed before supplementation and at 1, 2, 4, 6 and 8 weeks in the four groups (IV LOW, IV SUB, ORAL LOW, ORAL SUB). In addition, athletes completed a treadmill running test for running economy, lactate threshold and VO2max before and after supplementation.
RESULTS: Both forms of supplementation substantially increased ferritin levels in all four groups. IV supplementation resulted in higher ferritin in both IV groups compared with both ORAL groups from week 1 onwards. Haemoglobin concentration did not change substantially in any group. Hbmass increased in IV LOW (mean; 90% Confidence limits) +4.9%; 1.1-8.9% and was accompanied by an increase in VO2max: +3.3%; 0.4-6.3% and run time to exhaustion: +9.3%; 0.9-18.3%.
CONCLUSION: IV supplementation can effectively increase iron stores in iron deficient runners within 6 weeks and, if Hbmass is compromised, may enhance endurance capacity by facilitating erythropoiesis. Hbmass appears a more sensitive tool for measuring changes in whole body haemoglobin than haemoglobin concentration and may be useful in the diagnosis and follow-up for iron deficiency.
Authors:
Laura A Garvican; Philo U Saunders; Tanusha Cardoso; Iain C Macdougall; Louisa M Lobigs; Ruth Fazakerley; Kieran E Fallon; Bev Anderson; Judith M Anson; Kevin G Thompson; Christopher J Gore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-18
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 National Institute of Sports Studies, University of Canberra, Canberra, Australia 2 Australian Institute of Sport, Canberra, Australia 3 King's College Hospital, London, United Kingdom.
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