Document Detail

Intravenous Immunoglobulin Treatment Increased Live Birth Rate in a Spanish Cohort of Women with Recurrent Reproductive Failure and Expanded CD56(+) Cells.
MedLine Citation:
PMID:  22509929     Owner:  NLM     Status:  Publisher    
PROBLEM: Natural killer (NK, CD3(-) CD56(+) /CD16(+) ) and NKT-like cells (CD3(+) CD56(+) /CD16(+) ) activity is considered among the key factors for reproductive success. In the absence of immunological screening, beneficial effects of intravenous immunoglobulin (IVIG) in preventing recurrent reproductive failure (RRF) have not been reported. Here, we analyse the IVIG influence on pregnancy success in women with RRF and circulating NK or/and NKT-like cells expansion. METHOD OF STUDY: One hundred fifty-seven women with previous recurrent miscarriage and/or recurrent implantation failure after in vitro fertilization were consecutively studied. Sixty-four patients with CD56(+) cell expansion, no apparent underlying disease and who maintained their desire to conceive were selected. Forty of them received IVIG during pregnancy. RESULTS: Overall, the clinical pregnancy rate for the women under IVIG therapy was 92.5% and the live birth rate was 82.5%. Significantly lower pregnancy and live birth rates (25% and 12.5%, respectively) were observed for the patients with recurrent pregnancy loss and NK/NKT-like cells expansion without IVIG. After three cycles of IVIG, NK cell percentages decreased significantly and these values persisted throughout gestation. CONCLUSION: Intravenous immunoglobulin therapy for women with RRF and NK or NKT-like cell expansion was a safe and beneficial therapeutic strategy that associated with high clinical pregnancy and live birth rates.
Manuela Moraru; Javier Carbone; Diana Alecsandru; Marcela Castillo-Rama; Aurea García-Segovia; Juana Gil; Bárbara Alonso; Angel Aguarón; Rocío Ramos-Medina; Juan Martínez de María; Desamparados Oliver-Miñarro; Margarita Rodríguez-Mahou; Virginia Ortega; Pedro Caballero; Elena Meliá; Juan Vidal; Malena Cianchetta-Sivori; Carmen Esteban; Loreto Vargas-Henny; Jonathan Dale; Luis Ortiz-Quintana; Eduardo Fernández-Cruz; Silvia Sánchez-Ramón
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Clinical Immunology Unit, Department of Immunology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Immunology, Hospital Univesitario Puerta de Hierro Majadahonda, Madrid, Spain.
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