| Intravenous Contrast Agent Influence on Thoracic Computed Tomography Simulation Investigated ThroughAHeterogeneous Dose Calculation MethodUsing5-Bulk Densities. | |
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MedLine Citation:
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PMID: 21383608 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Using 5-bulk-density heterogeneous dose calculation, we investigated whether contrast-enhanced (CE+) computed tomography (CT) will affect dose-calculation accuracy in the thoracic area. METHODS: We analyzed 17 radiation-oncology patients who underwent thoracic CE+ CTs. Full-resolution CT and 5-bulk-density plans were generated using an adaptive convolution algorithm. Bulk densities for air, lung, fat, soft tissue, and bone were applied to regions identified by an isodensity segmentation tool. The population-averaged physical density of each region was calculated and compared with the reference value calculated from 66 noncontrast-enhanced (CE-) thoracic CT images. Using the 5-bulk densities, we created a new plan in which the physical densities of each area were forced to be the same as the CE- reference value, and we compared the dose-volume histograms (DVH). RESULTS: Average physical density for the segmented air, lung, fat, soft tissue, and bone for CE+ were 0.14, 0.29, 0.90, 1.03, and 1.13 g/cm, and the reference values for CE- were 0.14, 0.26, 0.89, 1.02, and 1.12 g/cm, respectively. In all the cases, the normal-tissue DVH agreed to better than 1%. In 15 cases, DVH of the planning target volume (PTV) agreed to better than 3%. In 2 patients, >3% difference in the PTV dose was observed. CONCLUSIONS: Only 2 patients with a strong injection artifact in the PTV or beam showed >3% discrepancy in the target dose. When using CE+ CT for treatment planning, strong injection artifacts must be excluded. |
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Authors:
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Anneyuko I Saito; Jonathan G Li; Chihray Liu; Kenneth R Olivier; Shinsuke Kyougoku; James F Dempsey |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-4 |
Journal Detail:
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Title: American journal of clinical oncology Volume: - ISSN: 1537-453X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207754 Medline TA: Am J Clin Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Radiology, Juntendo University Urayasu Hospital, Urayasu, Japan †Department of Radiation Oncology, University of Florida, Gainesville, FL ‡Department of Radiation Oncology, Mayo Clinic, Rochester, MI §ViewRay Inc, Cleveland, OH. |
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