Document Detail

Intravascular volume and fluid therapy for severe sepsis.
MedLine Citation:
PMID:  7922385     Owner:  NLM     Status:  MEDLINE    
Hypovolemia is one of the principal defects contributing to cardiovascular instability and circulatory failure during septic shock. Fluid infusion is the mainstay of initial resuscitation. Large amounts of fluids may be required and should be titrated to optimal hemodynamic effects while attempting to minimize the development of pulmonary and systemic edema. Hemoglobin and hematocrit should be carefully monitored, with transfusions being used as necessary to maintain adequate levels of systemic oxygen delivery. Crystalloids and colloids are equally effective, although the volume of fluids required with crystalloids is two to four times that of colloids. In older patients, where high filling pressures may be required for optimal hemodynamic effect, colloids may be associated with a lower frequency of pulmonary edema.
M E Astiz; A Galera-Santiago; E C Rackow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  New horizons (Baltimore, Md.)     Volume:  1     ISSN:  1063-7389     ISO Abbreviation:  New Horiz     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1994-10-25     Completed Date:  1994-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9416195     Medline TA:  New Horiz     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-36     Citation Subset:  IM    
St. Vincent's Hospital and Medical Center, New York, NY 10011.
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MeSH Terms
Blood Volume
Cardiac Volume
Cardiovascular Physiological Phenomena
Fluid Therapy*
Hemodynamics / physiology*
Shock, Septic / physiopathology,  therapy*
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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