Document Detail

Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings.
MedLine Citation:
PMID:  9704286     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: The authors compare the usefulness of intravascular ultrasound (IVUS) and magnetic resonance imaging (MRI) for quantitation of atherosclerosis in hyperlipidemic rabbits, correlated with histopathology. METHODS: Magnetic resonance imaging with T1- and T2-weighted spin echo sequences and three-dimensional time-of-flight MR angiography of the abdominal aorta was performed on seven rabbits using a 1.5 T MR imager and a standard head coil. X-ray angiography and IVUS examination (3.5 F/30 MHz imaging catheter) was performed via carotid artery access. RESULTS: Time-of-flight MR angiography source images provided the best resolution and plaque-lumen contrast in visual comparison between the different MRI sequences. Intra- and interobserver reproducibilities of the lesion thickness and area measurements were similar in IVUS and MRI (Pearson correlations 0.52-0.97; P < 0.01). The measurements from IVUS and MRI correlated closely with each other as well as with those made from histopathologic specimens (Pearson correlations 0.50-0.79; P < 0.001). The measurements from IVUS were somewhat more accurate than those made from MRI. CONCLUSIONS: Both MRI and IVUS with clinically available imaging equipments are feasible and accurate for the quantitation of experimental atherosclerosis of rabbit aorta.
H I Manninen; R L Vanninen; M Laitinen; H Räsänen; P Vainio; J S Luoma; T Pakkanen; H Tulla; S Ylä-Herttuala
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  33     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-20     Completed Date:  1998-10-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-71     Citation Subset:  IM    
Department of Clinical Radiology, Kuopio University Hospital, University of Kuopio, Finland.
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MeSH Terms
Aorta, Abdominal / pathology,  ultrasonography
Aortic Diseases / diagnosis*,  pathology,  ultrasonography
Arteriosclerosis / complications,  diagnosis*,  pathology,  ultrasonography
Hyperlipidemias / complications,  pathology
Magnetic Resonance Angiography
Magnetic Resonance Imaging*
Observer Variation
Ultrasonography, Interventional*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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