Document Detail

Intravascular ultrasound imaging after excimer laser angioplasty.
MedLine Citation:
PMID:  7954768     Owner:  NLM     Status:  MEDLINE    
To help elucidate the mechanism of excimer laser coronary angioplasty (ELCA), intravascular ultrasound (IVUS) imaging was performed in 19 of 29 patients who were treated with ELCA. The results were compared with a non-randomized control group of 18 patients who had IVUS studies both before and after PTCA alone. After ELCA alone, lumen diameter (1.9 x 1.7 mm) and lumen cross-sectional area (CSA) (2.9 mm2) by IVUS were not significantly different from baseline values in the patients before PTCA alone (2.1 x 1.8 mm, 3.2 mm2). After balloon dilatation in the laser treated group, lumen diameter (2.5 x 2.1 mm) and lumen CSA (4.9 mm2) were significantly greater than those post ELCA alone. However, there was no difference in lumen CSA or atheroma CSA in the group treated with excimer laser plus balloon dilatation vs. these measurements in the group treated with PTCA alone. ELCA does not ablate a large amount of atheroma (9% reduction) but creates a pathway to permit easier passage of a PTCA balloon. These quantitative and morphologic results may help explain why the restenosis rate with ELCA is similar to PTCA alone.
J Honye; D J Mahon; S Nakamura; J Wallis; A al-Zarka; S Saito; M Berns; J M Tobis
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Catheterization and cardiovascular diagnosis     Volume:  32     ISSN:  0098-6569     ISO Abbreviation:  Cathet Cardiovasc Diagn     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-11-29     Completed Date:  1994-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7508512     Medline TA:  Cathet Cardiovasc Diagn     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  IM    
Division of Cardiology, University of California, Irvine, Orange 92668-3298.
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MeSH Terms
Angioplasty, Laser* / adverse effects
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Artery Disease / pathology,  surgery*,  ultrasonography*
Coronary Vessels / pathology
Middle Aged
Treatment Outcome
Ultrasonography, Interventional*
Grant Support
5 P41 RR01192/RR/NCRR NIH HHS; 5 RO1 HL45677-02/HL/NHLBI NIH HHS

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