Document Detail

Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall.
MedLine Citation:
PMID:  21361689     Owner:  NLM     Status:  MEDLINE    
Laser speckle imaging (LSI) is a novel technique for measuring the mechanical properties of atherosclerotic plaques. In LSI, the decorrelation time constant of speckle intensity fluctuations provides an index of viscoelasticity that is closely related to plaque microstructure and composition. Here, we demonstrate for the first time, the feasibility of conducting LSI in vivo using a prototype 1.5 mm (4.5 Fr) diameter intravascular catheter. Investigation of the catheter performance using human arterial samples ex vivo shows that plaque time constants measured by the LSI catheter correlate well with those measured using a free-space bulk optics system. To demonstrate LSI in vivo, the catheter is interfaced with a portable console for intravascular evaluation in the aorta of a living rabbit. Distinct differences in arterial time constants are identified at normal aortic and stented sites in vivo with intravascular LSI.
Zeinab Hajjarian; Jingqun Xi; Farouc A Jaffer; Guillermo J Tearney; Seemantini K Nadkarni
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  16     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-06-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  026005     Citation Subset:  IM    
Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA.
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MeSH Terms
Aorta / physiology*,  ultrasonography*
Elastic Modulus / physiology
Elasticity Imaging Techniques / instrumentation*
Equipment Design
Equipment Failure Analysis
Grant Support
R21 HL 088306/HL/NHLBI NIH HHS; R21 HL 088306-02S1/HL/NHLBI NIH HHS

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