| Intravascular irradiation using Re-186 liquid-filled balloon catheters: correlation between experimental and theoretical studies. | |
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MedLine Citation:
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PMID: 10828567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Optimization of intravascular radiation to reduce stenosis following coronary angioplasty requires the ability to predict the patterns of radiation dose distribution. This investigation evaluated the agreement between Monte Carlo simulations and experimental radiation dose measurements for a radioisotope liquid-filled balloon catheter in a tissue equivalent phantom. METHODS AND MATERIALS: Direct measurements of the radiation dose from Re-186 liquid-filled balloons were made using thermoluminescent dosimeters (TLDs) and radiochromic film. Monte Carlo simulations were carried out using the Monte Carlo N-Particle code system (MCNP4B). RESULTS: The Monte Carlo generated dose values agreed with the experimentally determined results within the statistical uncertainty. A slightly higher penetration was indicated by regression analysis for the TLD data relative to the MCNP4B prediction that may be due to experimental configuration anomalies. For this balloon catheter, approximately 55 mCi of Re-186 will deliver 15 Gy at a 0.5 mm depth in tissue equivalent material in 5 min. CONCLUSIONS: Correlation between experimentally measured dose values and Monte Carlo computation supports the position that MCNP4B simulations constitute a valuable tool for investigating various clinical therapy designs. The agreement between Monte Carlo calculations and experiments provide confidence in applying MCNP4B to more sophisticated geometries of interest, and other methods of intravascular radiation dose delivery. |
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Authors:
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A J McGoron; W M Kassing; S R Thomas; R C Samaratunga; R G Pratt; H R Elson; D W Pipes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular radiation medicine Volume: 1 ISSN: 1522-1865 ISO Abbreviation: Cardiovasc. Radiat. Med. Publication Date: 1999 Oct-Dec |
Date Detail:
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Created Date: 2001-03-05 Completed Date: 2001-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888865 Medline TA: Cardiovasc Radiat Med Country: United States |
Other Details:
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Languages: eng Pagination: 368-75 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Cincinnati, Ohio, USA. mcgoron@eng.fiu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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instrumentation* Brachytherapy / instrumentation, methods* Computer Simulation Coronary Disease / radiotherapy*, therapy Humans Monte Carlo Method Phantoms, Imaging Radiation Dosage Radioisotopes / therapeutic use* Rhenium / therapeutic use* Thermoluminescent Dosimetry |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 7440-15-5/Rhenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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