| Intravascular imaging of atherosclerotic human coronaries in a porcine model: a feasibility study. | |
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MedLine Citation:
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PMID: 17503218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To perform intravascular imaging of atherosclerotic human coronary conduits in an animal model under conditions of flow and cardiac motion that approximate those encountered in vivo. BACKGROUND: Given the lack of animal models of vulnerable plaque, a model which would allow imaging of human disease and simulate coronary motion and blood flow could advance the development of emerging technologies to detect vulnerable plaques. METHODS: Human coronary segments from adult cadaver hearts were prepared as xenografts. In anesthetized Yorkshire pigs (45-50 kg) the chest was opened and the exposed aorta and right atrium were cannulated and attached in an end-to-end fashion to the human coronary xenograft, forming an aorto-atrial conduit. The xenograft was fixed to the anterior wall of the heart to simulate motion. Angiography and intravascular ultrasound (IVUS) of each graft were performed. RESULTS: Twelve human coronary grafts (10 from right coronary segments) were prepared and implanted successfully in seven animals. All animals tolerated the procedure. The average graft length was 39 +/- 2.3 mm. Blood flow rates distal to the graft were >100 ml/min in nine grafts. IVUS was performed in all 12 grafts and documented expansion of arterial (6.9%) and luminal (9.3%) dimensions during the cardiac cycle (P < 0.001 for both). There was a wide range of coronary atherosclerotic pathology within the grafts, including intimal thickening, fibrocalcific plaque, and deep lipid pools. CONCLUSION: This human-to-porcine coronary xenograft model allows intravascular imaging of human coronary pathology under conditions of blood flow and motion, and may be used to develop technologies aimed at identifying high-risk plaques. |
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Authors:
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Sergio Waxman; Kamal Khabbaz; Raymond Connolly; Jing Tang; Alexandra Dabreo; Lara Egerhei; Fumiyuki Ishibashi; James E Muller; Guillermo M Tearney |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-15 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 24 ISSN: 1569-5794 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-07 Completed Date: 2008-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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Department of Medicine and the Center for Translational Cardiovascular Research, Tufts-New England Medical Center, Boston, MA, USA. sergio.waxman@lahey.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Coronary Angiography* Coronary Artery Disease / pathology*, physiopathology, radiography, surgery, ultrasonography Coronary Vessels / pathology*, physiopathology, surgery, ultrasonography Disease Models, Animal Feasibility Studies Hemodynamics Humans Research Design Swine Transplantation, Heterologous Ultrasonography, Interventional* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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