Document Detail


Intravascular imaging of atherosclerotic human coronaries in a porcine model: a feasibility study.
MedLine Citation:
PMID:  17503218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To perform intravascular imaging of atherosclerotic human coronary conduits in an animal model under conditions of flow and cardiac motion that approximate those encountered in vivo. BACKGROUND: Given the lack of animal models of vulnerable plaque, a model which would allow imaging of human disease and simulate coronary motion and blood flow could advance the development of emerging technologies to detect vulnerable plaques. METHODS: Human coronary segments from adult cadaver hearts were prepared as xenografts. In anesthetized Yorkshire pigs (45-50 kg) the chest was opened and the exposed aorta and right atrium were cannulated and attached in an end-to-end fashion to the human coronary xenograft, forming an aorto-atrial conduit. The xenograft was fixed to the anterior wall of the heart to simulate motion. Angiography and intravascular ultrasound (IVUS) of each graft were performed. RESULTS: Twelve human coronary grafts (10 from right coronary segments) were prepared and implanted successfully in seven animals. All animals tolerated the procedure. The average graft length was 39 +/- 2.3 mm. Blood flow rates distal to the graft were >100 ml/min in nine grafts. IVUS was performed in all 12 grafts and documented expansion of arterial (6.9%) and luminal (9.3%) dimensions during the cardiac cycle (P < 0.001 for both). There was a wide range of coronary atherosclerotic pathology within the grafts, including intimal thickening, fibrocalcific plaque, and deep lipid pools. CONCLUSION: This human-to-porcine coronary xenograft model allows intravascular imaging of human coronary pathology under conditions of blood flow and motion, and may be used to develop technologies aimed at identifying high-risk plaques.
Authors:
Sergio Waxman; Kamal Khabbaz; Raymond Connolly; Jing Tang; Alexandra Dabreo; Lara Egerhei; Fumiyuki Ishibashi; James E Muller; Guillermo M Tearney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-15
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  24     ISSN:  1569-5794     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Affiliation:
Department of Medicine and the Center for Translational Cardiovascular Research, Tufts-New England Medical Center, Boston, MA, USA. sergio.waxman@lahey.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Coronary Angiography*
Coronary Artery Disease / pathology*,  physiopathology,  radiography,  surgery,  ultrasonography
Coronary Vessels / pathology*,  physiopathology,  surgery,  ultrasonography
Disease Models, Animal
Feasibility Studies
Hemodynamics
Humans
Research Design
Swine
Transplantation, Heterologous
Ultrasonography, Interventional*

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