| Intravascular haemolysis and increased prevalence of myeloma and monoclonal gammopathy in congenital dyserythropoietic anaemia, type III. | |
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MedLine Citation:
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PMID: 8299769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A family with congenital dyserythropoietic anaemia type III was studied. Twenty patients and 10 of their healthy siblings were clinically examined and questioned about their medical history. Blood sampling and bone marrow aspirations were also performed. Forty-five percent of the patients reported symptoms of anaemia and 35% regularly felt weakness, fatigue, or headache. However, the majority of the patients regarded themselves as healthy. The bone marrow showed a uniform picture of erythroid hyperplasia with multinuclear erythroblasts and gigantoblasts with up to 12 nuclei. There was laboratory evidence of intravascular haemolysis and mild anaemia. We also observed a high prevalence of monoclonal gammopathy of undetermined significance (3 cases) and myeloma (1 case) among the patients. |
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Authors:
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H Sandström; A Wahlin; M Eriksson; I Bergström; S N Wickramasinghe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of haematology Volume: 52 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-03-09 Completed Date: 1994-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 42-6 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, University Hospital, Umeå, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Dyserythropoietic, Congenital
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complications*,
genetics,
pathology Bone Marrow / pathology Female Genes, Dominant Hemolysis Humans Male Multiple Myeloma / pathology Paraproteinemias / complications Pedigree |
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