Document Detail

Intravascular gas exchange.
MedLine Citation:
PMID:  10218369     Owner:  NLM     Status:  MEDLINE    
Intravascular gas exchange, in which miniaturized hollow fibre oxygenators are inserted into the caval veins, has been proposed as a simpler and safer alternative to extracorporeal support in severe respiratory failure. One such device, the IVOX (intravascular oxygenator), has undergone clinical trials (160 implants) and, despite individual benefits, was found to be limited in its gas exchanging capacity. The peculiarities of oxygen physiology render pre-pulmonary oxygenation inefficient and variable, whereas carbon dioxide clearance is much more predictable. Several devices are currently undergoing development and may offer substantially enhanced gas exchange. The new devices, which may be several years from widespread clinical assessment, offer exciting therapeutic options in severe respiratory failure but are unlikely to completely replace extracorporeal techniques in the most severe forms of respiratory failure.
B F Keogh; K M Sim; T W Evans
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  54     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Adult Intensive Care Unit, Royal Brompton Hospital, London, UK.
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MeSH Terms
Equipment Design
Oxygen / blood
Oxygenators, Membrane*
Pulmonary Gas Exchange*
Respiratory Insufficiency / therapy*
Respiratory Therapy / instrumentation
Reg. No./Substance:

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