| Intravascular beta-amyloid infusion increases blood pressure: implications for a vasoactive role of beta-amyloid in the pathogenesis of Alzheimer's disease. | |
| | |
MedLine Citation:
|
PMID: 10400067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hypertension has been recognized as a risk factor for Alzheimer's disease (AD). Moreover, serum beta-amyloid (A beta) levels are elevated in several mutations linked to familial AD, as well as in some sporadic AD individuals. To determine the in vivo effects of A beta on blood pressure, A beta(1-40) was infused intra-arterially into anesthetized rats. For all animals, strong correlations exist between pre-infusion mean arterial blood pressure (MA beta) and post-arterial infusion increases in blood pressure. In spontaneously hypotensive animals, A beta infusion resulted in substantial increases in MA beta compared to vehicle distilled water infusion. A beta(1-40) was also able to accelerate MA beta return from induced hypotension, but infusion of A beta(1-42), or rat amylin had no such effect. These results provide evidence that circulating A beta(1-40) can exert vasopressor actions in vivo. Moreover, they suggest a pathophysiologic role for vascular A beta in AD that precedes A beta deposition and dementia onset. |
| | |
Authors:
|
G W Arendash; G C Su; F C Crawford; K B Bjugstad; M Mullan |
Related Documents
:
|
241067 - The pharmacology of new ethylenediamine derivatives (rom-126, rom-131, mk-142) with ant... 4037 - Increased mucociliary transport by adrenergic stimulation. 22774407 - Reduction of the morning blood pressure surge treated with olmesartan in chinese patien... 25017 - Sympathetic responsiveness and antihypertensive effect of beta-receptor blockade in ess... 9159627 - Dynamic cardiac compression improves contractile efficiency of the heart. 8023997 - Coronary pressure-flow autoregulation protects myocardium from pressure-induced changes... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroscience letters Volume: 268 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1999 Jun |
Date Detail:
|
Created Date: 1999-10-05 Completed Date: 1999-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 17-20 Citation Subset: IM |
Affiliation:
|
Department of Biology, University of South Florida, Tampa 33620, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
etiology*,
physiopathology* Amyloid beta-Protein / pharmacology* Animals Blood Pressure / drug effects* Female Infusions, Intra-Arterial Rats Rats, Sprague-Dawley Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Amyloid beta-Protein; 0/Vasoconstrictor Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronology of upper limb anticipatory postural adjustments associated with voluntary wrist flexions ...
Next Document: Music effects on event-related potentials of humans on the basis of cultural environment.