Document Detail

Intravascular Ultrasound and Histology Findings in Very Late Bare-Metal Stent Thrombosis.
MedLine Citation:
PMID:  21144414     Owner:  NLM     Status:  Publisher    
Very late thrombosis in an implanted bare-metal stent is a very uncommon event outside the context of brachytherapy and few data about its pathophysiology are available. We performed an intravascular ultrasound study during primary angioplasty in five patients with very late bare-metal stent thrombosis and carried out a histological analysis of the material removed by manual thrombectomy. The mean time from the index procedure was 7±4 years. Intravascular ultrasound findings were: calcified atherosclerosis with in-stent plaque rupture, complex plaque in the distal segment of the stent, in-stent neointimal proliferation associated with underexpansion, and severe in-stent proliferation. Histological findings were consistent with the intravascular ultrasound images: recent thrombus with areas of old thrombosis in all cases and remnant atheromatous plaque and endothelium. Consequently, in-stent or distal stent atherosclerosis progression and progressive neointimal proliferation were the likely pathophysiological mechanisms.
Angel Sánchez-Recalde; Elvira González-Obeso; Roberto Martín Reyes; Santiago Jiménez-Valero; Guillermo Galeote; Luis Calvo; Raúl Moreno; José L López Sendón
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Publication Detail:
Journal Detail:
Title:  Revista espanola de cardiologia     Volume:  63     ISSN:  1579-2242     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404277     Medline TA:  Rev Esp Cardiol     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  1492-1496     Citation Subset:  -    
Sección de Hemodinámica y Cardiología Intervencionista. Servicio de Cardiología. Hospital Universitario La Paz. Madrid. España.
Vernacular Title:
Hallazgos de ecografía intravascular e histológicos de trombosis muy tardías de stents convencionales.
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