Document Detail

Intrauterine wound healing in a 20 week human fetus.
MedLine Citation:
PMID:  155931     Owner:  NLM     Status:  MEDLINE    
Limb amputations, probably caused by amniotic constriction bands, were examined histologically in a 20 week human fetus to assess the degree of intrauterine healing. No acute inflammatory process, no removal of necrotic material, and no granulation tissue formation were seen at any of the amputation sites. A recent ulcer, probably caused by friction of an exposed piece of bone in the stump of the right leg, also showed no inflammatory response. Healing was by coagulation of exposed tissue and by a minor degree of mesenchymal proliferation without repair. Similar changes have been described in experimental intrauterine wound healing in rats, lambs, opossums and baboons. Conversion from a non-specific to a classical postnatal inflammatory response occurs sometime before term. It is not known at what point this change takes place in man; examination of this infant suggests that it occurs after the twentieth week of gestation.
U Rowlatt
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histology     Volume:  381     ISSN:  0340-1227     ISO Abbreviation:  Virchows Arch A Pathol Anat Histol     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7505137     Medline TA:  Virchows Arch A Pathol Anat Histol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  353-61     Citation Subset:  IM    
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MeSH Terms
Amputation, Traumatic / pathology
Fetal Diseases / pathology
Granulation Tissue
Wound Healing*

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