Document Detail


Intrauterine tobacco exposure may alter auditory brainstem responses in newborns.
MedLine Citation:
PMID:  20367434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study of tobacco exposure and auditory processes was conducted in a predominantly low-income population of 40 pregnant women and their newborns. Urinary cotinine concentrations and self-reported smoking status were obtained from the mother during the first prenatal care visit. Auditory brainstem-evoked responses (ABRs) were recorded in neonates to assess neuroelectrical activity of the auditory nerve following a sound stimulus. Infants of mothers with the highest cotinine concentrations (> 1,000 ng/ml) responded at a rate that was four times greater (hazard ratio 4.1, 95% confidence interval 1.4-11.5) than infants of non-smoking mothers (cotinine <or= 15 ng/ml). Associations with more moderate cotinine concentrations (> 15-1,000 ng/ml) were not observed. Enhanced ABRs may disrupt auditory processes related to speech perception, negatively affecting reading and language development during childhood. The results suggest that tobacco exposure during pregnancy may impair auditory function.
Authors:
Jennifer David Peck; Barbara Neas; Candace Robledo; Eva Saffer; Laura Beebe; Robert A Wild
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  592-6     Citation Subset:  IM    
Affiliation:
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA. jennifer-peck@ouhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cohort Studies
Cotinine / urine
Evoked Potentials, Auditory, Brain Stem / drug effects*
Female
Humans
Infant, Newborn
Pregnancy
Prenatal Exposure Delayed Effects*
Smoking / adverse effects*
Grant Support
ID/Acronym/Agency:
T42 OH008421-03/OH/NIOSH CDC HHS
Chemical
Reg. No./Substance:
486-56-6/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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