Document Detail


Intrauterine therapy for homozygous alpha-thalassemia.
MedLine Citation:
PMID:  7724145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Alpha-thalassemia is one of the most common genetic disorders in the world and is becoming more common in the United States with the increase in immigration of susceptible populations. This disease has been stated previously to be incompatible with extrauterine life. CASE: A Filipino woman with a prior loss due to hemoglobin Bart's underwent prenatal diagnosis that confirmed recurrence in the index pregnancy. Intravascular intrauterine exchange transfusions maintained appropriate fetal growth. A cesarean delivery yielded a 2190-g male infant with minor malformations. The postnatal course was characterized by mild respiratory insufficiency. Postnatal chronic transfusion therapy is underway pending consideration for bone marrow transplantation. CONCLUSION: Antenatal diagnosis and therapy of homozygous alpha-thalassemia can prevent the prenatal consequences of hydrops and fetal death. New technologies such as stem cell transplantation may help to avert both prenatal and postnatal consequences.
Authors:
S Carr; L Rubin; D Dixon; J Star; J Dailey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  85     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-05-22     Completed Date:  1995-05-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  876-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Maternal-Fetal Medicine, Brown University School of Medicine/Women and Infants Hospital, Providence, Rhode Island, USA.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / ultrasonography
Adult
Apgar Score
Blood Transfusion, Intrauterine
Cesarean Section
Exchange Transfusion, Whole Blood
Female
Genetic Counseling
Homozygote
Humans
Hydrops Fetalis / ultrasonography*
Infant, Newborn
Male
Philippines / ethnology
Pregnancy
Pregnancy Complications, Hematologic*
Recurrence
Respiratory Distress Syndrome, Newborn / diagnosis*
Ultrasonography, Prenatal
alpha-Thalassemia / genetics*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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