Document Detail

Intrauterine programming of bone. Part 1: alteration of the osteogenic environment.
MedLine Citation:
PMID:  17701093     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We have investigated this in a rat model of maternal protein insufficiency.
METHODS: Dams received either 18% w/w (control) or 9% w/w (low protein) diet during pregnancy, and the offspring were studied at selected time points (4, 8, 12, 16, 20, 47 weeks).
RESULTS: Alkaline phosphatase activity in controls reached peak levels from 8 to 20 weeks of age. In contrast, restricted diet offspring were at peak levels from 4 weeks of age. Peak levels were similar in both groups. Serum IGF-1 levels were lower in female restricted diet offspring at 4 weeks of age, and serum osteocalcin was significantly higher at 4 weeks of age in male and female offspring from mothers fed the restricted diet, whereas serum 25-OH vitamin D was significantly lower in restricted diet males at 8, 12, and 20 weeks of age.
CONCLUSIONS: These data indicate that a low protein diet in utero affected the osteogenic environment in the offspring with effects that persist into late adulthood. These results indicate the key role of the nutritional environment in early development on programming of skeletal development with implicit consequences in later life.
S A Lanham; C Roberts; C Cooper; R O C Oreffo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-15
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  19     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-07-17     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-56     Citation Subset:  IM    
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MeSH Terms
Aging / physiology
Alkaline Phosphatase / metabolism
Birth Weight
Bone Marrow Cells / enzymology
Bone and Bones / embryology*,  physiopathology
Calcifediol / blood
Cells, Cultured
Diet, Protein-Restricted*
Insulin-Like Growth Factor I / analysis
Litter Size
Osteocalcin / blood
Osteogenesis / physiology*
Prenatal Exposure Delayed Effects / physiopathology*
Prenatal Nutritional Physiological Phenomena
Rats, Wistar
Weight Gain
Grant Support
G0400491//Medical Research Council; MC_UP_A620_1014//Medical Research Council
Reg. No./Substance:
0/insulin-like growth factor-1, mouse; 104982-03-8/Osteocalcin; 67763-96-6/Insulin-Like Growth Factor I; EC Phosphatase; P6YZ13C99Q/Calcifediol

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