| Intrauterine pregnancy following low-dose gonadotropin ovulation induction and direct intraperitoneal insemination for severe cervical stenosis. | |
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MedLine Citation:
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PMID: 12450413 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: We present a case of primary infertility related to extreme cervical stenosis, a subset of cervical factor infertility which accounts for approximately 5% of all clinical infertility referrals. CASE PRESENTATION: A 37 year-old nulligravida was successfully treated with ovulation induction via recombinant follicle stimulating hormone (FSH) and direct intraperitoneal insemination (IPI). Anticipating controlled ovarian hyperstimulation with in vitro fertilization/embryo transfer (IVF), the patient underwent hysteroscopy and cervical recanalization, but safe intrauterine access was not possible due to severe proximal cervical stricture. Hysterosalpingogram established bilateral tubal patency and confirmed an irregular cervical contour. Since the cervical canal could not be traversed, neither standard intrauterine insemination nor transcervical embryo transfer could be offered. Prepared spermatozoa were therefore placed intraperitoneally at both tubal fimbria under real-time transvaginal sonographic guidance using a 17 gage single-lumen IVF needle. Supplementary progesterone was administered as 200 mg/d lozenge (troche) plus 200 mg/d rectal suppository, maintained from the day following IPI to the 8th gestational week. A singleton intrauterine pregnancy was achieved after the second ovulation induction attempt. CONCLUSIONS: In this report, we outline the relevance of cervical factor infertility to reproductive medicine practice. Additionally, our andrology evaluation, ovulation induction approach, spermatozoa preparation, and insemination technique in such cases are described. |
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Authors:
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E Scott Sills; Gianpiero D Palermo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2002-Nov-26 |
Journal Detail:
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Title: BMC pregnancy and childbirth Volume: 2 ISSN: 1471-2393 ISO Abbreviation: BMC Pregnancy Childbirth Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-Dec-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100967799 Medline TA: BMC Pregnancy Childbirth Country: - |
Other Details:
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Languages: ENG Pagination: 9 Citation Subset: - |
Affiliation:
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Georgia Reproductive Specialists LLC; Atlanta, Georgia USA. dr.sills@ivf.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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