| Intrauterine parvovirus B19 infection may cause an asymptomatic or recurrent postnatal infection. | |
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MedLine Citation:
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PMID: 8414803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although infection with parvovirus B19 (B19) during pregnancy may cause fetal demise, the true incidence of intrauterine infection is unknown. For 19 women with serologically confirmed B19 infections between 4 and 38 weeks of gestation, we performed follow-up examinations of their infants. Serial sonograms of the 19 fetuses showed that none developed hydrops. All 19 women delivered healthy term infants. Cord sera of four infants were tested for IgM to B19 and three were positive. Between 3 and 21 months of age, all 19 infants had normal physical examinations, developmental evaluations and hematocrits; and 16 lacked IgG to B19. One infant who was IgM-positive to B19 at birth was IgM-positive at age 7 months when he also had an IgG titer to B19 of 1:500,000 (mother's concurrent titer, 1:10,000), and had B19 DNA in serum detected by polymerase chain reaction. The other two infants who were IgM-positive at birth were IgM- and IgG-negative by 11 and 16 months of age. These results suggest that intrauterine B19 infection may be frequent and occasionally cause an asymptomatic postnatal infection. |
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Authors:
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W C Koch; S P Adler; J Harger |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 12 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-11-23 Completed Date: 1993-11-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 747-50 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Medical College of Virginia, Richmond 23298-0163. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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blood Erythema Infectiosum* / immunology, transmission Female Fetal Diseases / immunology, microbiology* Follow-Up Studies Humans Immunoglobulin G / blood Immunoglobulin M / blood Infant Male Parvovirus B19, Human / immunology Pregnancy Pregnancy Complications, Infectious* Recurrence |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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