Document Detail

Intrauterine nutrition: its importance during critical periods for cardiovascular and endocrine development.
MedLine Citation:
PMID:  9882734     Owner:  NLM     Status:  MEDLINE    
Experimental investigations in animals have highlighted the role of early reduced calorie and protein nutrition on fetal cardiovascular development, and the occurrence of a transition from a low fetal arterial blood pressure in late gestation to a high arterial blood pressure postnatally. These observations may explain the correlation between health, including appropriate nutrition, in pregnant women and the outcome of their pregnancies. Emphasis has been placed on low birth weight infants who have an increased risk of developing cardiovascular diseases, including hypertension, coronary heart disease and stroke in adulthood. Vascular pathology in adults is not always associated with low birth weight and animal experiments indicate that substantial changes in cardiovascular and endocrine function can result from maternal or fetal undernutrition without impairing fetal growth. Experimental investigation on organogenesis shows the pivotal role of adequate protein availability as well as total caloric intake. Amino acid metabolism in the feto-maternal unit appears to have a key influence on the development of organs involved in chronic degenerative disease in the adult. Experimental investigation has also highlighted the role of carbohydrate metabolism and its effect on the fetus in this respect. Either restriction of protein intake or diabetes in pregnant rats has intergenerational effects at least on the endocrine pancreas and the brain. Further investigation is needed to clarify the mechanisms involved and lead to a new understanding of the importance of nutrition during pregnancy. This will provide an important approach to the primary prevention of diabetes and chronic degenerative diseases.
J J Hoet; M A Hanson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of physiology     Volume:  514 ( Pt 3)     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-26     Completed Date:  1999-03-26     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  617-27     Citation Subset:  IM    
Laboratoire de Biologie Cellulaire, Universite Catholique de Louvain, Place Croix du Sud 5, 1348 Louvain-la-Neuve, Belgium.
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MeSH Terms
Animal Nutritional Physiological Phenomena
Cardiovascular System / embryology*
Endocrine System / embryology*,  physiology
Fetus / physiology*
Nutritional Physiological Phenomena / physiology*

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