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Intrauterine insulin resistance in fetuses of overweight mothers.
MedLine Citation:
PMID:  22690802     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  To investigate the relationship between maternal overweight and fetal insulin resistance. Material and Methods:  Nineteen overweight and 30 lean pregnant women were recruited in the present study. Maternal and fetal insulin resistance were determined by measuring sex hormone binding globulin (SHBG) concentrations in maternal venous or umbilical cord serum, respectively. Maternal age, gestational age, height, pre-gravidity weight, pre-partum weight, as well as fetal gender, birth weight, birth height, and head circumference were collected as clinical data. Results:  Fetuses of overweight mothers had larger birth weight (3.58 ± 0.55 kg vs 3.32 ± 0.42, adjusted P = 0.006) and lower SHBG concentrations (26.64 ± 3.65 vs 34.36 ± 7.84, adjusted P = 0.007) than those of lean mothers after values were adjusted for potential cofactors. Fetal SHBG level was negatively correlated with pre-gravidity body mass index (R = -0.392, adjusted P = 0.025) and weight gain during pregnancy (R = -0.332, adjusted P = 0.026) even with adjustment for potential cofactors. Among the 29 pregnant women with gestational diabetes mellitus, the overweight mothers had higher H1AC levels than their lean counterparts (6.47 ± 0.44 vs 5.74 ± 0.52, adjusted P = 0.004). Conclusion:  Intrauterine insulin resistance is more prominent in fetuses of overweight mothers, an effect that is decreased by weight gain control during pregnancy.
Authors:
Bin Liu; Yun Xu; Jian-Ming Liang; Courtney Voss; Huan-Yu Xiao; Wei-Yang Sheng; Yan-Hong Sun; Zi-Lian Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-13
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  -     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.
Affiliation:
Department of Obstetrics and Gynecology Clinical Laboratory, The First Affiliated Hospital Department of Endocrinology, The Sixth Affiliated Hospital Zhong-shan Medical School, Sun Yat-sen University, Guangzhou, China Department of Biochemistry, University of Western Ontario, London, Ontario, Canada.
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