| Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. | |
| | |
MedLine Citation:
|
PMID: 10221698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed five predictive variables as regards pregnancy: number of the treatment cycle (P = 0.009), duration of infertility (P = 0.017), age (P = 0.028), number of follicles (P = 0.031) and infertility aetiology (P = 0.045). The odds ratios for age < 40 years, unexplained infertility aetiology (versus endometriosis) and duration of infertility < or = 6 years were 3.24, 2.79 and 2.33, respectively. A multifollicular ovarian response to clomiphene citrate/HMG resulted in better treatment success than a monofollicular response, and 97% of the pregnancies were obtained in the first four treatment cycles. The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women < 40 years of age with infertility duration < or = 6 years, who do not suffer from endometriosis. |
| | |
Authors:
|
S Nuojua-Huttunen; C Tomas; R Bloigu; L Tuomivaara; H Martikainen |
Related Documents
:
|
7571238 - Infertility due to antisperm antibodies. 12856518 - Endometrial abnormalities in infertile women. 8925318 - Shift work and subfecundity: a european multicenter study. european study group on infe... 19328468 - Low uptake of prenatal diagnosis after established carrier status of a balanced structu... 11508328 - Mercury and selenium concentrations in maternal and neonatal scalp hair: relationship t... 14646518 - Induction of apoptosis by a gonadotropin-releasing hormone agonist during early pregnan... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Human reproduction (Oxford, England) Volume: 14 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1999 Mar |
Date Detail:
|
Created Date: 1999-06-10 Completed Date: 1999-06-10 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 698-703 Citation Subset: IM |
Affiliation:
|
The Family Federation of Finland (The Oulu Infertility Clinic). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Clomiphene
/
therapeutic use Cost-Benefit Analysis Female Health Care Costs Humans Infertility / therapy* Insemination, Artificial, Homologous* / economics Logistic Models Male Menotropins / therapeutic use Ovulation Induction* / economics Pregnancy Pregnancy Outcome* Pregnancy, Multiple Prognosis Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
61489-71-2/Menotropins; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sperm treatment with extracellular ATP increases fertilization rates in in-vitro fertilization for m...
Next Document: Laparoscopy-assisted intrapelvic sonography with a high-frequency, real-time miniature transducer fo...