Document Detail

Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome.
MedLine Citation:
PMID:  10221698     Owner:  NLM     Status:  MEDLINE    
A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed five predictive variables as regards pregnancy: number of the treatment cycle (P = 0.009), duration of infertility (P = 0.017), age (P = 0.028), number of follicles (P = 0.031) and infertility aetiology (P = 0.045). The odds ratios for age < 40 years, unexplained infertility aetiology (versus endometriosis) and duration of infertility < or = 6 years were 3.24, 2.79 and 2.33, respectively. A multifollicular ovarian response to clomiphene citrate/HMG resulted in better treatment success than a monofollicular response, and 97% of the pregnancies were obtained in the first four treatment cycles. The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women < 40 years of age with infertility duration < or = 6 years, who do not suffer from endometriosis.
S Nuojua-Huttunen; C Tomas; R Bloigu; L Tuomivaara; H Martikainen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  14     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  698-703     Citation Subset:  IM    
The Family Federation of Finland (The Oulu Infertility Clinic).
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MeSH Terms
Clomiphene / therapeutic use
Cost-Benefit Analysis
Health Care Costs
Infertility / therapy*
Insemination, Artificial, Homologous* / economics
Logistic Models
Menotropins / therapeutic use
Ovulation Induction* / economics
Pregnancy Outcome*
Pregnancy, Multiple
Retrospective Studies
Reg. No./Substance:
61489-71-2/Menotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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