Document Detail

Intrauterine growth restriction and risk for arterial hypertension: a causal relationship?
MedLine Citation:
PMID:  17624937     Owner:  NLM     Status:  MEDLINE    
AIMS: Intrauterine growth restriction (IUGR) has been demonstrated to have serious consequences for health in adult age. These include an increased risk for metabolic syndrome, pulmonary and cardiovascular disorders. These disorders are in part secondary to the development of arterial hypertension, which has been demonstrated to be more frequent in individuals subjected to restricted intrauterine growth. METHODS: A review on publications on pathogenesis and epidemiology of hypertension associated to IUGR. RESULTS: Current concepts for this association include a reduced nephrogenesis and increased arterial stiffness, impaired sympathetic regulation and steroid metabolism secondary to IUGR. Early postnatal risk-modifying factors include among others catch-up growth leading to childhood overweight. CONCLUSION: IUGR increases the risk of hypertension in adult life. Identifying relevant risk factors for arterial hypertension will be the basis for the development of preventive concepts to be applied for predisposed individuals.
Ludwig Gortner
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  35     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
University Children's Hospital, University of the Saarland, Germany.
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MeSH Terms
Birth Weight / physiology*
Blood Pressure / physiology*
Blood Vessels / growth & development
Fetal Development / physiology*
Fetal Growth Retardation / physiopathology*,  prevention & control
Hypertension / physiopathology*
Kidney / growth & development

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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